HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells
HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells
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DOI：
10.4049/jimmunol.178.5.3265
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发表时间：
2007-03-01
影响因子：
4.4
通讯作者：
Cao, Huyen
中科院分区：
文献类型：
--
作者：
Elrefaei, Mohamed;Ventura, Florence L.;Cao, Huyen
产生IL-10的T细胞抑制Ag特异性CD 8（+）T细胞应答，并可能在HIV感染中观察到的免疫失调中发挥作用。我们先前已经观察到在晚期HIV疾病中存在HIV特异性IL-10阳性CD 8（+）T细胞。在这项研究中，我们检查了GAG特异性IL-10阳性CD 8（+）T细胞的抑制功能。去除这些IL-10阳性CD 8（+）T细胞导致HIV和人CMV特异性CD 8（+）T细胞的细胞溶解和IL-2产生增加，但不产生IFN-γ。此外，这些IL-10阳性CD 8（+）T细胞通过直接细胞-细胞接触介导抑制，与其他调节性T细胞相比具有独特的免疫表型特征。我们描述了一种新的抑制性CD 8（+）T细胞群体在晚期HIV感染，可能有助于在HIV感染中观察到的免疫功能障碍。
IL-10 producing T cells inhibit Ag-specific CD8(+) T cell responses and may play a role in the immune dysregulation observed in HIV infection. We have previously observed the presence of HIV-specific IL-10-positive CD8(+) T cells in advanced HIV disease. In this study, we examined the suppressive function of the Gag-specific IL-10-positive CD8(+) T cells. Removal of these IL-10-positive CD8(+) T cells resulted in increased cytolysis and IL-2, but not IFN-gamma, production by both HIV- and human CMV-specific CD8(+) T cells. In addition, these IL-10-positive CD8(+) T cells mediated suppression through direct cell-cell contact, and had a distinct immunophenotypic profile compared with other regulatory T cells. We describe a new suppressor CD8(+) T cell population in advanced HIV infection that may contribute to the immune dysfunction observed in HIV infection.