3D Spectral domain optical coherence tomography findings in choroidal tumors
3D Spectral domain optical coherence tomography findings in choroidal tumors
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DOI：
10.5301/ejo.2010.5848
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发表时间：
2011-05-01
影响因子：
1.7
通讯作者：
Singh, Arun D.
中科院分区：
文献类型：
--
作者：
Sayanagi, Kaori;Pelayes, David E.;Singh, Arun D.
目的.目的探讨脉络膜痣与脉络膜黑色素瘤的三维谱域光学相干断层扫描（SD-OCT）特征，以及其他脉络膜肿瘤的OCT特征。用3D SD-OCT（OCT-1000; Topcon Inc.，Paramus，NJ）。分析图像是否存在SD-OCT发现，如视网膜色素上皮（RPE）/脉络膜毛细血管反射率、RPE不规则性、玻璃疣、RPE下积液、RPE厚度、视网膜下存款、视网膜下积液、视网膜内水肿、视网膜厚度和感光细胞内外段连接（IS/OS）。同时评估脉络膜肿瘤的可视化及其内在反射率OCT特征。与痣相比，视网膜下存款、视网膜下积液和视网膜内水肿在恶性黑色素瘤眼中更常见（p < 0.001）。肿瘤的SD-OCT可视化仅限于前部。脉络膜痣、不确定性病变、黑色素瘤和转移性病变具有可变的内在反射模式。血管瘤的内在特征包括脉络膜空洞，而骨瘤表现出高的内在反射率。SD-OCT提供了有用的信息来观察和记录继发于脉络膜肿瘤的视网膜和RPE变化，有助于区分脉络膜痣和恶性黑色素瘤。需要改进当前OCT系统以更好地表征脉络膜肿瘤的内在特征。
Purpose. To report the optical coherence tomographic features differentiating choroidal nevus from choroidal melanoma by 3D spectral-domain optical coherence tomography (SD-OCT) and OCT characteristics of other choroidal tumors.Methods. A total of 67 consecutive eyes with choroidal tumors including choroidal nevus (25 eyes), indeterminate choroidal melanocytic lesion (11 eyes), malignant melanoma (23 eyes), metastasis (4 eyes), hemangioma (2 eyes), and osteoma (2 eyes) were imaged with 3D SD-OCT (OCT-1000; Topcon Inc., Paramus, NJ). The images were analyzed for the presence or absence of SD-OCT findings such as retinal pigment epithelium (RPE)/choriocapillaris reflectivity, RPE irregularity, drusen, sub-RPE fluid, RPE thickness, subretinal deposit, subretinal fluid, intraretinal edema, retinal thickness, and photoreceptor inner and outer segment junction (IS/OS). Visualization of the choroidal tumor and its intrinsic reflectivity OCT features were also assessed.Results. When compared with nevus, subretinal deposit, subretinal fluid, and intraretinal edema were detected significantly more frequently in the eyes with malignant melanoma (p < 0.001). SD-OCT visualization of the tumor was limited only to the anterior aspect. Choroidal nevus, indeterminate lesions, melanoma, and metastatic lesions had variable intrinsic reflectivity pattern. Intrinsic features of hemangioma included choroidal hollowness whereas osteoma demonstrated high intrinsic reflectivity.Conclusions. SD-OCT provides useful information to observe and document the retinal and RPE changes secondary to choroidal tumors that help differentiate choroidal nevus from malignant melanoma. Improvements in the current OCT systems are needed to better characterize intrinsic features of choroidal tumors.