Body Mass Index and Attempted Suicide: Cohort Study of 1,133,019 Swedish Men
Body Mass Index and Attempted Suicide: Cohort Study of 1,133,019 Swedish Men
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DOI：
10.1093/aje/kwq274
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发表时间：
2010-10-15
影响因子：
5
通讯作者：
Rasmussen, Finn
中科院分区：
文献类型：
--
作者：
Batty, G. David;Whitley, Elise;Rasmussen, Finn
最近有报道称，体重指数(BMI)与自杀未遂(非致命性)之间存在关联。然而，现有的为数不多的研究规模相对较小，大部分是横断面的，结果相互矛盾。作者在一大群出生于1950至1976年间的1,133,019名瑞典男性中探索了BMI与自杀未遂之间的联系，并在成年早期测量了BMI。在平均23.9年的随访中，共有18,277名(1.6%)男性因自杀未遂而入院至少1次。在调整了混杂因素后，在整个BMI范围内，随着BMI的增加，自杀未遂的发生率呈逐步线性下降(BMI的标准差增加，危险比=0.93，95%可信区间：0.91，0.94)。排除基线时患有抑郁症的男性的分析与基于完整队列的分析基本相同。在基线没有抑郁的男性中，控制随后的抑郁略微降低了试图自杀的风险增加，特别是在体重较低的男性中。这项研究表明，体重较低的男性自杀未遂的风险增加，相关因素可能延伸到“正常”的BMI范围。
Associations between body mass index (BMI) and attempted (nonfatal) suicide have recently been reported. However, the few existing studies are relatively small in scale, the majority cross-sectional, and results contradictory. The authors have explored BMI-attempted suicide associations in a large cohort of 1,133,019 Swedish men born between 1950 and 1976, with BMI measured in early adulthood. During a mean follow-up of 23.9 years, a total of 18,277 (1.6%) men had at least 1 hospital admission for attempted suicide. After adjustment for confounding factors, there was a stepwise, linear decrease in attempted suicide with increasing BMI across the full BMI range (per standard deviation increase in BMI, hazard ratio = 0.93, 95% confidence interval: 0.91, 0.94). Analyses excluding men with depression at baseline were essentially identical to those based on the complete cohort. In men free from depression at baseline, controlling for subsequent depression slightly attenuated the raised risk of attempted suicide, particularly in lower weight men. This study suggests that lower weight men have an increased risk of attempted suicide and that associations may extend into the "normal" BMI range.