Alternative Stimulation Intensities for Mapping Cortical Motor Area with Navigated TMS
Alternative Stimulation Intensities for Mapping Cortical Motor Area with Navigated TMS
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DOI：
10.1007/s10548-016-0470-x
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发表时间：
2016-05-01
期刊：
影响因子：
2.7
通讯作者：
Julkunen, Petro
中科院分区：
文献类型：
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作者：
Kallioniemi, Elisa;Julkunen, Petro
导航经颅磁刺激（nTMS）正在成为术前功能运动区标测的常用工具。标测中使用的刺激强度通常是相对于患者静息运动阈值（rMT）的阈上强度。对于应使用哪种阈上强度，以及选择适当刺激强度（SI）的最佳标准，目前尚无共识。在本研究中，使用运动诱发电位绘制了12名右利手志愿者（8名男性，年龄24-61岁）的左侧运动皮质，SI为rMT的110%和120%，阈值上限（UT）由Mills-Nithi算法估计。UT显著低于rMT的120%（p < 0.001），而UT与rMT的110%之间没有观察到显著差异（p = 0.112）。代表尺寸遵循类似的趋势，即基于UT（5.9 cm（2））和110% rMT（5.0 cm（2））计算的面积小于120% rMT（8.8 cm（2））（p
Navigated transcranial magnetic stimulation (nTMS) is becoming a popular tool in pre-operative mapping of functional motor areas. The stimulation intensities used in the mapping are commonly suprathreshold intensities with respect to the patient's resting motor threshold (rMT). There is no consensus on which suprathreshold intensity should be used nor on the optimal criteria for selecting the appropriate stimulation intensity (SI). In this study, the left motor cortices of 12 right-handed volunteers (8 males, age 24-61 years) were mapped using motor evoked potentials with an SI of 110 and 120 % of rMT and with an upper threshold (UT) estimated by the Mills-Nithi algorithm. The UT was significantly lower than 120 % of rMT (p < 0.001), while no significant difference was observed between UT and 110 % of rMT (p = 0.112). The representation sizes followed a similar trend, i.e. areas computed based on UT (5.9 cm(2)) and 110 % of rMT (5.0 cm(2)) being smaller than that of 120 % of rMT (8.8 cm(2)) (p