Homeostasis of cerebrospinal fluid has a role in early brain development
Homeostasis of cerebrospinal fluid has a role in early brain development
复制标题
DOI：
10.1097/wnr.0b013e3283582067
复制
发表时间：
2012-11-14
期刊：
影响因子：
1.7
通讯作者：
Bueno, David
中科院分区：
文献类型：
--
作者：
Castells, Anna;Parvas, Maryam;Bueno, David
胚胎脑脊液（E-CSF）是存在于脑腔中的含蛋白质的液体，在神经元发育和功能中起关键作用。从原发性脑神经发生开始，E-CSF组成和稳态通过瞬时血-CSF屏障功能精确调节，其控制蛋白质转运及其在脑内空腔的相对浓度。在E-CSF中发现的蛋白质之一是卵清蛋白，其被假定在营养中起作用。在这里，我们解决的问题，无论是在发育中的鸡胚神经上皮祖细胞使用卵白蛋白作为一种高度特异性的氨基酸营养来源，或者他们是否使用其他氨基酸来源，尽管事实上，他们不能从血清运输到脑腔在生理条件下。虽然没有发现卵清蛋白是神经发生和细胞存活所需的关键蛋白质，但我们的观察结果加强了胚胎血-CSF屏障的关键作用，因为其对蛋白质转运和E-CSF稳态的精确调节确保了神经发育的最大效率。NeuroReport 23：917-921（C）2012年威科健康垂直酒吧Lippincott威廉姆斯&威尔金斯。
Embryonic cerebrospinal fluid (E-CSF) is a protein-containing fluid present in brain cavities that plays key roles in neuronal development and function. From the beginning of primary brain neurogenesis, E-CSF composition and homeostasis are precisely tuned by a transient blood-CSF barrier function, which controls protein transport and their relative concentration of within-brain cavities. One of the proteins found in E-CSF is ovalbumin, which is postulated to play a role in nutrition. Here, we address the question of whether neuroepithelial progenitor cells in developing chick embryos use ovalbumin as a highly specific nutritional source of amino acids or alternatively whether they use other amino acid sources, despite the fact that they cannot be transported from blood serum to brain cavities under physiological conditions. Although ovalbumin was not found to be a key protein required for neurogenesis and cell survival, our observations reinforce the crucial role of the embryonic blood-CSF barrier, as its precise regulation of protein transport and E-CSF homeostasis ensures the maximum efficiency of neural development. NeuroReport 23:917-921 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.