Tumor growth in rats: conditioned suppression of food intake and preference.
Tumor growth in rats: conditioned suppression of food intake and preference.
复制标题
大鼠肿瘤生长：条件性抑制食物摄入和偏好。
DOI：
10.1037//0735-7044.99.5.818
复制
发表时间：
1985
影响因子：
1.9
通讯作者：
Murowchick,E
中科院分区：
文献类型：
--
作者：
Bernstein,IL;Treneer,CM;Goehler,LE;Murowchick,E
在4个实验中，140只雄性同基因Wistar-Furth大鼠被植入肿瘤或接受对照切口。患有实验性肿瘤的Ss在肿瘤生长过程中对一种新的饮食产生了强烈的厌恶。当肿瘤生长过程中提供的食物是熟悉的实验室食物时，厌恶并不明显。习得性食物厌恶对肿瘤性厌食症的影响被证明为，在新饮食中维持的荷瘤鼠比在实验室食物中维持的荷瘤鼠更严重和持久的吞咽。因此，当一种饮食是习得性厌恶发展的显著目标时，对它发展的厌恶可能对肿瘤厌食症的整体综合征做出实质性贡献。与长期饮食相比，经常改变给荷瘤小鼠提供的饮食与较轻的厌食症有关。结果表明，预防习得性厌恶食物，或反复更换厌恶食物，可以最大限度地减少习得性厌恶食物的影响，减轻荷瘤动物的厌食症。（30 ref）（PsycINFO Database Record (c) 2016 APA，版权所有）
In 4 experiments, 140 male syngeneic Wistar-Furth rats were implanted with tumors or received control incisions. Ss with experimental tumors developed strong aversions to a novel diet they consumed during tumor growth. Aversions were not evident when the food available during tumor growth was familiar laboratory chow. The impact of learned food aversions on tumor anorexia was evidenced by more severe and long-lasting hypophagia in tumor-bearing Ss maintained on a novel diet than in those maintained on laboratory chow. Thus, when a diet was a salient target for the development of learned aversions, the aversions that developed to it could make substantial contributions to the overall syndrome of tumor anorexia. Frequent changes of the diet offered to tumor-bearing Ss were associated with milder anorexia than that produced by a constant diet. Results suggest that, the prevention of learned food aversions, or the repeated replacement of aversive foods, can minimize the impact of learned food aversions and attentuate anorexia in tumor-bearing animals.(30 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)