DIFFERENTIAL BAROREFLEX CONTROL OF HEART-RATE AND VASCULAR-RESISTANCE IN RABBITS - RELATIVE ROLE OF CAROTID, AORTIC, AND CARDIOPULMONARY BARORECEPTORS
DIFFERENTIAL BAROREFLEX CONTROL OF HEART-RATE AND VASCULAR-RESISTANCE IN RABBITS - RELATIVE ROLE OF CAROTID, AORTIC, AND CARDIOPULMONARY BARORECEPTORS
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DOI：
10.1161/01.res.50.4.554
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发表时间：
1982-01-01
影响因子：
20.1
通讯作者：
ABBOUD, FM
中科院分区：
文献类型：
--
作者：
GUO, GB;THAMES, MD;ABBOUD, FM
在动脉血压变化过程中，主动脉（ABR）、颈动脉窦（CBR）和迷走神经心肺压力感受器在心率和血管阻力反射控制中的相对作用进行了评估。给麻醉家兔静脉注射苯丙氨酸（PE）和硝酸甘油（NG）（氯醛糖-乌拉坦）。无论是CBR还是ABR的去神经（X）都显著损害了反射性心率反应。与此相反，反射血管反应在后肢（灌注恒定血流）被保存，除了反射血管收缩后ABRX轻微受损。完整CBR和ABR的迷走神经切断术仅损害反射性心动过缓。迷走神经切断术后，CBRX和ABRX均未显著改变反射性心率或血管反应，除了ABRX后反射性血管收缩受损。联合CBRX和ABRX消除了所有反射反应，除了PE期间的小心动过缓和灌注压（收缩-扩张）的双相变化。迷走神经切断术消除了心动过缓和扩张相，收缩相持续存在，并被腰交感神经切断术消除。当保留后肢阻力的反射控制时，心率的反射控制可能受损;心率的反射变化可能不能用作总循环的动脉压力感受器控制完整性的可靠指标。一组动脉压力感受器不补偿另一组的缺乏，以激活迷走神经元;相反，一组压力感受器完全补偿另一组的缺乏，以抑制交感神经元。心脏和其他压力感受器仅在PE诱导的动脉压大幅升高期间对反射反应的贡献最小。
The relative roles of aortic (ABR), carotid sinus (CBR) and vagal cardiopulmonary baroreceptors in the reflex control of heat rate and vascular resistance during changes in arterial blood pressure were assessed. Injections of phenylephrine (PE) and nitroglycerin (NG) were given i.v. to anesthetized rabbits (chloralose-urethane). Reflex heart rate responses were impaired significantly by denervation (X) of either CBR or ABR. In contrast, reflex vascular responses in the hindlimb (perfused at constant blood flow) were preserved except for a slight impairment of reflex vasoconstriction after ABRX. Vagotomy with intact CBR and ABR impaired only the reflex bradycardia. After vagotomy, neither CBRX nor ABRX altered significantly the reflex heart rate or vascular responses except, again for an impairment of reflex vasoconstriction after ABRX. Combined CBRX and ABRX eliminated all reflex responses except for a small bradycardia and a biphasic change in perfusion pressure (constrictor-dilator) during PE. Vagotomy eliminated the bradycardia and the dilator phase, the constrictor phase persisted and was abolished by lumbar sympathectomy. Reflex control of heart rate may be impaired when reflex control of hindlimb resistance is preserved; reflex changes in heart rate may not be used as a reliable index of the integrity of arterial baroreceptor control of the total circulation. One set of arterial baroreceptors does not compensate for the absence of the other with respect to activation of vagal neurons; in contrast, 1 set of baroreceptors compensates fully for the absence of the other with respect to inhibition of sympathetic neurons. Cardiopulmonary and other baroreceptors contribute minimally to reflex responses only during large PE-induced increases in arterial pressure.