Aqueous-based microcapsules are detected primarily in gut-associated dendritic cells after oral inoculation of mice.
Aqueous-based microcapsules are detected primarily in gut-associated dendritic cells after oral inoculation of mice.
复制标题
小鼠口服接种后，主要在肠道相关树突状细胞中检测到水基微胶囊。
DOI：
10.1016/s0264-410x(97)00108-4
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发表时间：
1997
期刊：
影响因子：
5.5
通讯作者：
Offita,PA
中科院分区：
文献类型：
--
作者：
Lomotan,EA;Brown,KA;Speaker,TJ;Offita,PA
我们之前发现，水基微囊在小鼠口服接种后增强了病毒特异性体液免疫反应。然而，微胶囊增强免疫原性的机制仍不清楚。我们发现，成年小鼠口服接种后，精胺-海藻酸盐微胶囊主要在肠道相关树突状细胞（即 CD11c/CD18+、Ia+、CD11b−、CD45R−）中检测到。微囊化可以通过涉及比自然感染期间募集的抗原呈递细胞更有效的抗原呈递细胞来增强免疫原性。
We previously found that aqueous-based microencapsulation enhanced virus-specific humoral immune responses after oral inoculation of mice. However, the mechanism by which microencapsulation enhances immunogenicity remains unclear. We found that spermine-alginate microcapsules were detected primarily in gut-associated dendritic cells (i.e. CD11c/CD18+, Ia+, CD11b−, CD45R−) after oral inoculation of adult mice. Microencapsulation may enhance immunogenicity by involving antigen presenting cells which are more efficient than those recruited during natural infection.