The third component of the complement (C3) is a marker of the risk of atherogenesis
The third component of the complement (C3) is a marker of the risk of atherogenesis
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DOI：
10.1097/01.hjr.0000224485.80349.76
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发表时间：
2006-08-01
影响因子：
--
通讯作者：
Mazzotta, Gianfranco
中科院分区：
文献类型：
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作者：
Capuano, Vincenzo;D'Arminio, Teodora;Mazzotta, Gianfranco
目的探讨补体第三组分(C3)与冠心病其他危险因素之间的关系。方法与结果我们对1200名年龄在25-74岁之间的人群(男600人，女600人)进行了调查。血清补体C3与体重指数(BMI，P<；0.01)和纤维蛋白原(P<；0.01)密切相关。我们发现与血小板计数(P<；0.01)、胰岛素水平(P<；0.01)、甘油三酯(P<；0.01)、低密度脂蛋白胆固醇(P<；0.01)显著独立相关，与吸烟(P<；0.01)呈负相关。
Aim The aim of this study was to assess the association between the third component of the complement (C3) and other risk factors of coronary heart disease.Methods and results We evaluated 1200 individuals aged 25-74 years (600 men and 600 women). A strong relationship was shown between serum C3 and both body mass index (BMI, P < 0.01) and fibrinogen (P < 0.01). We found a significant, independent correlation with: platelet count (P < 0.01), insulin level (P < 0.01), triglycerides (P < 0.01), low-density lipoprotein (LDL) cholesterol (P < 0.01), and an inverse correlation with cigarette smoking (P < 0.01).Conclusions A high concentration of C3 is a marker of a profile at risk of atherogenesis.