INVIVO HYBRIDIZATION OF HUMAN TUMOR AND NORMAL HAMSTER CELLS
INVIVO HYBRIDIZATION OF HUMAN TUMOR AND NORMAL HAMSTER CELLS
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DOI：
10.1038/250649a0
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发表时间：
1974-01-01
期刊：
影响因子：
64.8
通讯作者：
TSAO, MC
中科院分区：
文献类型：
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作者：
GOLDENBERG, DM;PAVIA, RA;TSAO, MC
当移植到异种宿主中时，肿瘤的侵袭性和转移性是非常罕见的1。在过去的7年中，我们多次观察到在仓鼠的脸颊袋中注射不同组织病理学的人类癌细胞后不久，仓鼠中侵袭性和转移性肿瘤的产生2 -7。我们认为这一生物学现象是由于人类肿瘤与正常仓鼠宿主细胞的体内融合所致2 -8，尽管不排除致癌病毒的参与。最近，出现了支持肿瘤与正常细胞在体内杂交的其他证据9。然而，这些事件在肿瘤过程中的重要性还有待于认识。
IT is exceedingly rare for neoplasms to be invasive and metastatic when grafted in xenogeneic hosts1. During the past 7 yr, we have on numerous occasions observed the production of invasive and metastatic tumours in hamsters soon after injecting human cancer cells of diverse histopathology into their cheek pouches2–7. We have interpreted this biological phenomenon as due to thein vivofusion of the human tumour with normal hamster host cells2–8, although the involvement of oncogenic viruses was not excluded. Recently, other evidence supporting the hybridisation of tumour with normal cellsin vivohas appeared9. The significance of such events in the neoplastic process, however, has yet to be appreciated.