Omega-3 fatty acids' supplementation in Alzheimer's disease: A systematic review
Omega-3 fatty acids' supplementation in Alzheimer's disease: A systematic review
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DOI：
10.1080/1028415x.2017.1321813
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发表时间：
2018-01-01
影响因子：
3.6
通讯作者：
Luft, Vivian Cristine
中科院分区：
文献类型：
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作者：
Canhada, Scheine;Castro, Kamila;Luft, Vivian Cristine
简介：阿尔茨海默病（AD）是一种神经退行性疾病，其特征在于记忆、语言、推理和其他认知功能的进行性损害。有证据表明，ω-3脂肪酸可能作为一个可能的保护因素在AD.目的：评估结果在文献中涉及ω-3脂肪酸补充剂及其对AD患者认知功能的影响.方法：MEDLINE的系统评价（来自PubMed），Excerpta Medica数据库，和科克伦图书馆数据库进行了系统性综述和荟萃分析指南的首选报告项目。纳入标准包括在原来的干预研究，安慰剂对照，评估补充或饮食摄入的omega-3脂肪酸对认知功能的影响，在人类AD，没有限制的黄金日期publish.Results：初步搜索结果在361篇文章。7项研究完全符合纳入标准。与安慰剂相比，大多数研究没有发现omega-3脂肪酸补充剂的统计学显著结果，并且那些显示出一些益处的人只在少数认知评估量表中表现出来。然而，omega-3脂肪酸的影响似乎是最有效地证明在非常轻度AD患者。结论：omega-3脂肪酸补充剂在轻度AD的影响证实了流行病学观察研究表明，omega-3脂肪酸可能是有益的疾病发作时，有轻微的脑功能损害。虽然一些研究表明，在更严重的情况下，认知功能量表会发生变化，但它们不足以支持在治疗AD时补充omega-3脂肪酸。
Introduction: Alzheimer's disease (AD) is a neurodegeneration disorder characterized by progressive impairments of memory, language, reasoning, and other cognitive functions. Evidence suggests that omega-3 fatty acids may act as a possible protection factor in AD.Objective: To evaluate the results available in the literature involving omega-3 fatty acids supplementation and its effect on cognitive function in AD patients.Methods: A systematic review of MEDLINE (from PubMed), Excerpta Medica Database, and Cochrane Library databases was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria consisted in original intervention studies, controlled by placebo, that assessed the impact of supplementation or dietary intake of omega-3 fatty acids on cognitive function, in humans with AD, without limitation for prime date of publication.Results: Initial search resulted in 361 articles. Seven studies fully met the inclusion criteria. Most studies did not find statistically significant results for the omega-3 fatty acids supplementation compared to placebo, and those who show some benefit do it only in a few cognitive assessment scales. However, the effects of omega-3 fatty acids appear to be most effectively demonstrated in patients with very mild AD.Conclusion: The effects of omega-3 fatty acids supplementation in mild AD corroborate epidemiological observational studies showing that omega-3 fatty acids may be beneficial in disease onset, when there is slight impairment of brain function. Although some studies have shown changes in scales of cognitive function in more severe cases, they are not enough to support omega-3 fatty acids supplementation in the treatment of AD.