Cutaneous necrosis after subcutaneous injection of polyethylene-glycol-modified interferon alpha.
Cutaneous necrosis after subcutaneous injection of polyethylene-glycol-modified interferon alpha.
复制标题
皮下注射聚乙二醇修饰干扰素α后皮肤坏死。
DOI：
10.1080/000155502320323360
复制
发表时间：
2002
影响因子：
3.6
通讯作者：
U. Jappe
中科院分区：
文献类型：
--
作者：
H. Kurzen;D. Petzoldt;W. Hartschuh;U. Jappe
实验室检查显示白细胞减少和贫血，长官，尽管血小板，电解质，肝酶，尿素和干扰素-a-2b都在正常范围内。丙型肝炎和恶性黑色素瘤的治疗从炎症边缘取皮肤活检（1，2）。以提高治疗舒适度和最佳病变。显微镜检查显示血管扩张伴红细胞外渗，但无血管炎的体征，聚乙二醇（PEG）修饰。表皮显示出几乎完整的干扰素-a-2b最近被引入。基底层注射性坏死（图2a）。因此，频率可以从每周3次减少到每周一次。我们报告的发展，皮肤坏死已经发生。注射真皮处的表皮和坏死（药物栓塞皮肤）的上部在被血管扩张包围的楔形中央部分坏死。皮下注射PEG修饰的艾德血管后，一些附件周围小部位由于内皮肿胀而部分闭塞。干扰素-a-2b治疗丙型肝炎2例淋巴细胞在血管周围和汗腺周围被发现。未观察到动脉血管或较大静脉闭塞。病例报告
Laboratory examinations revealed leukopenia and anemia, Sir, although thrombocytes, electrolytes, liver enzymes, urea and Interferon-a-2b has been shown to be eVective in the creatinine were within normal range. treatment of hepatitis C and malignant melanoma A skin biopsy was taken from the in ammatory margin of (1, 2). In order to improve treatment comfort and the rst lesion. Microscopic examination revealed dilatation of the vessels with extravasation of erythrocytes, but no signs eYcacy, polyethylene glycol (PEG) modi cation of of vasculitis. The epidermis showed an almost complete interferon-a-2b has recently been introduced. Injection necrosis of the basal layer (Fig. 2a). frequency can thus be reduced from 3 times a week to The second site was removed surgically before complete once a week. We report the development of a cutaneous necrosis had occurred. The epidermis and upper parts of the necrosis (embolia cutis medicamentosa) at the injection dermis were necrotic in a wedge-shaped central part surrounded by vasodilatation. Some of the periadnexial small site after subcutaneous injection of PEG-modi ed vessels were partly occluded due to endothelial swelling. interferon-a-2b in 2 patients with hepatitis C. Lymphocytes were found perivascularly and around the sweat glands. Occlusion of arterial vessels or larger veins was not observed. CASE REPORT