CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome.
CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome.
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DOI：
10.1111/his.12111
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发表时间：
2013-06
期刊：
影响因子：
6.4
通讯作者：
Suo Z
中科院分区：
文献类型：
--
作者：
Fan H;Yuan Y;Wang J;Zhou F;Zhang M;Giercksky KE;Nesland JM;Suo Z
探讨CD117在食管鳞状细胞癌（SCC）中的异常表达及其预后意义。对 157 例食管鳞状细胞癌患者和 10 例邻近肿瘤的正常食管上皮细胞的组织微阵列和常规组织切片进行 CD117 免疫组织化学染色。食管鳞状细胞癌组织中CD117表达阳性率为29.9%，而10例正常食管上皮组织中未检测到CD117表达。 CD117表达与T分期（P < 0.001）、远处转移（P = 0.015）、淋巴结转移（P = 0.019）和临床分期（P = 0.021）显着相关。 CD117阳性肿瘤患者的无进展生存期短于CD117阴性肿瘤患者（P = 0.010）。在单变量分析中，CD117表达是食管SCC患者总生存的最重要因素（P < 0.001），其次是淋巴结转移（P = 0.001）、T分期（P = 0.002）、临床分期（P = 0.006）、远处转移（P = 0.020）和组织学分级（P = 0.027）。多变量分析证实CD117表达是食管SCC患者的独立预后标志物（P = 0.002）。此外，CD117 表达预示着无远处转移的患者生存率较差。可手术食管鳞状细胞癌中的 CD117 表达可能是一个有价值的预后标志物，检测其在临床样本中的表达可能有助于定义临床结果极差的食管鳞状细胞癌亚类，这可能需要专门的针对性治疗方式。
To investigate the aberrant expression of CD117 in oesophageal squamous cell carcinoma (SCC) and its prognostic significance. Immunohistochemical staining for CD117 was performed on tissue microarray and routine tissue sections from 157 oesophageal SCC patients and 10 normal oesophageal epithelia adjacent to tumour. The positive rate of CD117 expression was 29.9% in oesophageal SCC tissues, whereas no CD117 expression was detected in the 10 normal oesophageal epithelia. CD117 expression was significantly associated with T stage (P < 0.001), distant metastasis (P = 0.015), lymph node metastasis (P = 0.019), and clinical stage (P = 0.021). Progression-free survival in the patients with CD117-positive tumours was shorter than that in the patients with CD117-negative tumours (P = 0.010). In univariate analyses, CD117 expression was the most significant factor for overall survival of oesophageal SCC patients (P < 0.001), followed by lymph node metastasis (P = 0.001), T stage (P = 0.002), clinical stage (P = 0.006), distant metastasis (P = 0.020), and histological grade (P = 0.027). Multivariate analyses verified that CD117 expression was an independent prognostic marker for oesophageal SCC patients (P = 0.002). In addition, CD117 expression predicted poorer survival in patients without distant metastases. CD117 expression in operable oesophageal SCC may be a valuable prognostic marker, and detection of its expression in clinical samples may be useful in defining a subclass of oesophageal SCCs with extremely poor clinical outcome, which may require a specially targeted treatment modality.
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