Relationship between maternal phthalate exposure and offspring size at birth.
Relationship between maternal phthalate exposure and offspring size at birth.
复制标题
DOI：
10.1016/j.scitotenv.2017.08.207
复制
发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Yingshuang Zhu;Yanjian Wan;Bin Zhang;Aifen Zhou;W. Huo;Chuansha Wu;Hongxiu Liu;Yangqian Jiang
中科院分区：
文献类型：
--
作者：
Yingshuang Zhu;Yanjian Wan;Bin Zhang;Aifen Zhou;W. Huo;Chuansha Wu;Hongxiu Liu;Yangqian Jiang
关于产前邻苯二甲酸盐暴露对胎儿生长影响的研究结果并不一致。来自动物研究的越来越多的证据表明，邻苯二甲酸盐对胎儿生长有潜在的性别特异性影响，但目前的人体数据有限。在这项研究中，我们旨在估计母亲邻苯二甲酸盐暴露与婴儿出生尺寸之间的关系。对来自中国健康婴儿队列（HBC）的孕妇（n= 1002）尿液样本中六种主要邻苯二甲酸盐代谢物水平进行了测量。使用线性回归模型估计尿邻苯二甲酸酯代谢物水平与出生尺寸（出生体重、出生长度、出生体重z分数和庞德勒指数）之间的关系。在男孩中，n转化的邻苯二甲酸二-2-乙基己酯（DEHP）代谢物水平与出生体重和出生体重z分数的增加显著相关。此外，每增加1个单位的邻苯二甲酸单（2-乙基-5-羧基-戊基）（MECPP），男孩的ponderal指数就会增加0.25 kg/m3[95%可信区间（CI）： 0.03, 0.47]。然而，我们没有观察到母体邻苯二甲酸酯代谢物水平与女孩的任何结果有任何显著关联。我们的数据表明，母亲邻苯二甲酸盐暴露与出生体重和体重指数增加之间存在潜在的性别特异性关联，而这种关联仅在男孩中表现明显。
Research findings on effects of prenatal phthalate exposure on fetal growth were inconsistent. Increasing evidence from animal studies has indicated a potential sex-specific effect of phthalates on fetal growth, but the current human data was limited. In this study, we aimed to estimate the relationships between maternal phthalate exposure and infant birth size. Six major phthalate metabolite levels of urine samples were measured among pregnant women (n= 1002) from the Healthy Baby Cohort (HBC), China. The associations between urinary phthalate metabolites levels and birth size (birth weight, birth length, birth weight z-scores and ponderal index) were estimated using linear regression models. In boys, the ln-transformed di-2-ethylhexyl phthalate (DEHP) metabolite levels were significantly associated with increased birth weight and birth weight z-scores. Additionally, each ln-unit increase in mono-(2-ethyl-5-carbox-ypentyl) phthalate (MECPP) was associated with a 0.25 kg/m3[95% confidence interval (CI): 0.03, 0.47] increase in ponderal index in boys. However, we did not observe any significant association of maternal phthalate metabolite levels with any of the outcomes in girls. Our data suggested potential sex-specific associations of maternal phthalate exposure with increased birth weight and ponderal index, which were merely apparent in boys.