Do high or low doses of anxiolytics and hypnotics affect mismatch negativity in schizophrenic subjects? An EEG and MEG study
Do high or low doses of anxiolytics and hypnotics affect mismatch negativity in schizophrenic subjects? An EEG and MEG study
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DOI：
10.1016/s1388-2457(01)00710-6
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发表时间：
2002-01-01
影响因子：
4.7
通讯作者：
Kato, N
中科院分区：
文献类型：
--
作者：
Kasai, K;Yamada, H;Kato, N
目的：许多研究已经证明精神分裂症中的失配负性（MMN）减弱。最近，研究人员发现 GABA 能抑制神经元可能调节 MMN 的生成。考虑到相当一部分精神分裂症患者接受与 GABA(A) 受体有亲和力的抗焦虑药和安眠药来减轻焦虑和睡眠障碍的共病症状，我们需要评估抗焦虑药/安眠药是否可能影响他们的 MMN 生成。本研究的目的是利用事件相关电位 (ERP) 和脑磁图 (MEG) 评估精神分裂症受试者接受高剂量或低剂量的抗焦虑药/安眠药影响其失配阴性 (MMN) 的可能性。方法：分别有 23 名和 16 名精神分裂症患者参加了 ERP 和 MEG 研究。记录了三种类型的 MMN（MMN 对纯音刺激持续时间变化的响应、类别内元音变化（日语元音 /a/ 持续时间短与长）和跨类别元音变化（元音 /a/ 与 /o/）。结果：在 ERP 或 MEG 的任何条件下，高或低剂量的苯二氮卓类药物对 MMN 振幅 / 磁性 MMN 功率、地形 / 偏侧性或潜伏期没有显着影响研究结论：这些结果表明，长期服用抗焦虑药/安眠药不会显着影响精神分裂症患者的 MMN。 (C) 2002 Elsevier Science Ireland Ltd. 保留所有权利。
Objective: Many studies have demonstrated mismatch negativity (MMN) attenuation in schizophrenia. Recently, investigators have shown that GABAergic inhibitory neurons may regulate MMN generation. Considering that a substantial proportion of schizophrenic patients receive anxiolytics and hypnotics that have affinity to GABA(A) receptors to reduce their comorbid symptoms of anxiety and sleep disturbances, we need to assess whether anxiolytics/hypnotics might affect their MMN generation. The aim of this study is to assess the possibility that high or low doses of anxiolytics/hypnotics received by schizophrenic subjects affect their mismatch negativity (MMN), using event-related potentials (ERPs) and magnetoencephalography (MEG).Methods: Twenty-three and 16 patients with schizophrenia participated in the ERP and MEG studies, respectively. Three types of MMN (MMN in response to a duration change of pure-tone stimuli, within-category vowel change (Japanese vowel /a/ with short versus long duration), and across-category vowel change (vowel /a/ versus /o/)) were recorded.Results: High or low doses of benzodiazepine had no significant effects on MMN amplitude/magnetic MMN power, topography/laterality, or latency under any conditions of the ERP or MEG study.Conclusions: These results suggest that chronic administration of anxiolytics/hypnotics does not significantly affect MMN in schizophrenia. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.