Choline and betaine intake is inversely associated with breast cancer risk: A two‐stage case‐control study in China
Choline and betaine intake is inversely associated with breast cancer risk: A two‐stage case‐control study in China
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DOI：
10.1111/cas.12064
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发表时间：
2013-02
期刊：
影响因子：
5.7
通讯作者：
Caixia Zhang;Mei-xia Pan;Bin Li;Lian Wang;X. Mo;Yu-ming Chen;Fang‐Yu Lin;S. Ho
中科院分区：
文献类型：
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作者：
Caixia Zhang;Mei-xia Pan;Bin Li;Lian Wang;X. Mo;Yu-ming Chen;Fang‐Yu Lin;S. Ho
很少有流行病学研究评估胆碱和甜菜碱摄入量与乳腺癌风险的关系，结果仍然不一致。本研究旨在评估中国女性膳食中胆碱和甜菜碱摄入量与乳腺癌风险的关系。采用两阶段病例对照研究，807例病例和807例年龄(5年间隔)和居住地(城乡)相匹配的对照。通过面对面访谈，使用有效的食物频率问卷来评估膳食摄入量。采用非条件Logistic回归模型计算多变量调整后的优势比(OR)和95%可信区间(CI)。研究发现，饮食中胆碱和甜菜碱的摄入量与乳腺癌风险呈显著负相关。总胆碱摄入量的调整OR为0.40(95%CI=0.28~0.57，P趋势及t；0.001)，甜菜碱摄入量的调整OR为0.58(95%CI=0.42~0.80，P趋势及t；0.001)，胆碱加甜菜碱摄入量的调整OR为0.38(0.27~0.53，P趋势及t；0.001)。个别胆碱化合物、来自甘油磷胆碱的胆碱、磷胆碱、磷脂酰胆碱、鞘磷脂和游离胆碱的摄入量也与乳腺癌风险负相关。胆碱摄入量与乳腺癌风险之间的负相关主要限于叶酸水平较低的参与者(每天242g)，与胆碱摄入量的第四四分位数和第一四分位数相比，OR(95%CI)为0.46(0.23-0.91)(P趋势=0.005)。目前的研究表明，摄入胆碱和甜菜碱与患乳腺癌的风险成反比。胆碱摄入量与乳腺癌风险的关系可能会被叶酸摄入量改变。
Few epidemiological studies have evaluated the association of choline and betaine intake with breast cancer risk and the results remain inconsistent. This study aimed to assess the relationship between dietary intake of choline and betaine and the risk of breast cancer among Chinese women. A two‐stage case‐control study was conducted, with 807 cases and 807 age‐ (5‐year interval) and residence (rural/urban)‐matched controls. A validated food frequency questionnaire was used to assess dietary intake by face‐to‐face interview. An unconditional logistic regression model was used to calculate multivariate‐adjusted odds ratios (OR) and 95% confidence intervals (CI). A significant inverse association was found between dietary choline and betaine consumption and breast cancer risk. The adjusted OR for the highest quartile of intake compared with the lowest were 0.40 (95% CI = 0.28–0.57, Ptrend < 0.001) for total choline intake, 0.58 (95% CI = 0.42–0.80, Ptrend < 0.001) for betaine intake and 0.38 (0.27–0.53, Ptrend < 0.001) for choline plus betaine intake, respectively. Intakes of individual choline compouds, choline from glycerophosphocholine, phosphocholine, phosphatidylcholine, sphingomyelin and free choline were also negatively associated with breast cancer risk. The inverse association between choline intake and breast cancer risk was primarily confined to participants with low folate level (<242 g/day), with an OR (95% CI) of 0.46 (0.23–0.91) comparing the fourth quartile with the first quartile of choline intake (Ptrend = 0.005). The present study suggests that consumption of choline and betaine is inversely associated with the risk of breast cancer. The association of choline intake with breast cancer risk is probably modified by folate intake.