Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin
Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin
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DOI：
10.1016/s0960-894x(02)00066-5
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发表时间：
2002-03-25
影响因子：
2.7
通讯作者：
Hori, H
中科院分区：
文献类型：
--
作者：
Kasai, S;Nagasawa, H;Hori, H
We designed and synthesized the antiangiogenic arginine-rich dendrimers, TX-1943 and TX-1944, which mimic the surface structure of endostatin. TX-1944 containing 16 arginine residues is more similar in surface structure to endostatin than TX1943 with eight arginine residues, and has stronger in vivo antiangiogenic activity at 10 mug/CAM in the chicken embryo chorioallantoic membrane (CAM) assay. TX-1944 also has stronger activity to bind heparin and to inhibit the growth of rat lung endothelial (RLE) cells than TX-1943. (C) 2002 Elsevier Science Ltd. All rights reserved.
