Polycomb group protein Ezh2 controls actin polymerization and cell signaling
Polycomb group protein Ezh2 controls actin polymerization and cell signaling
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DOI：
10.1016/j.cell.2005.02.029
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发表时间：
2005-05-06
期刊：
影响因子：
64.5
通讯作者：
Tarakhovsky, A
中科院分区：
文献类型：
--
作者：
Su, I;Dobenecker, MW;Tarakhovsky, A
多梳组蛋白Ezh2是从果蝇到小鼠的生物体发育的关键调节因子之一，通过调节组蛋白甲基化发挥其表观遗传功能。在这里，我们报告存在的胞浆EZH2含甲基转移酶复合物和领带的功能，这种复杂的调节肌动蛋白聚合在各种类型的细胞。遗传学证据支持细胞溶质Ezh2在肌动蛋白聚合依赖性过程中的重要作用，例如T细胞中的抗原受体信号传导和成纤维细胞中PDGF诱导的背侧圆形皱褶形成。Ezh2的功能揭示了赖氨酸甲基化在调节核和核外信号传导过程中的更广泛用途。
Polycomb group protein Ezh2, one of the key regulators of development in organisms from flies to mice, exerts its epigenetic function through regulation of histone methylation. Here, we report the existence of the cytosolic Ezh2-containing methyltransferase complex and tie the function of this complex to regulation of actin polymerization in various cell types. Genetic evidence supports the essential role of cytosolic Ezh2 in actin polymerization-dependent processes such as antigen receptor signaling in T cells and PDGF-induced dorsal circular ruffle formation in fibroblasts. Revealed function of Ezh2 points to a broader usage of lysine methylation in regulation of both nuclear and extra-nuclear signaling processes.