Formation of monodisperse calcium alginate microbeads by rupture of water-in-oil-in-water droplets with an ultra-thin oil phase layer
Formation of monodisperse calcium alginate microbeads by rupture of water-in-oil-in-water droplets with an ultra-thin oil phase layer
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DOI：
10.1039/c003918g
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发表时间：
2010-01-01
期刊：
影响因子：
6.1
通讯作者：
Ichikawa, Sosaku
中科院分区：
文献类型：
--
作者：
Saeki, Daisuke;Sugiura, Shinji;Ichikawa, Sosaku
报道了一种由具有超薄油相层的水包油(W/O/W)液滴形成单分散海藻酸钙微球的新方法。利用微流控装置，将内水相中含有海藻酸钠的W/O/W液滴作为海藻酸钙微珠的模板。W/O/W液滴的超薄油相层因内外水相之间的渗透压差而破裂。破裂后，内水相中的聚阴离子海藻酸盐与外水相扩散的钙离子发生交联化，形成单分散的球形海藻酸钙微珠。
This paper reports a novel formation method of monodisperse calcium alginate microbeads from water-in-oil-in-water (W/O/W) droplets with an ultra-thin oil phase layer. W/O/W droplets containing sodium alginate in an internal aqueous phase were formed as a template of calcium alginate microbeads using a microfluidic device. The ultra-thin oil phase layer of the W/O/W droplets was ruptured by an osmotic pressure difference between the internal and external aqueous phase. Immediately after the rupture, polyanionic alginate in the internal aqueous phase was cross-linked with calcium ion diffused from the external aqueous phase, and monodisperse and spherical calcium alginate microbeads were formed.