Hypothesis on renal mechanism of non-dipper pattern of circadian blood pressure rhythm
Hypothesis on renal mechanism of non-dipper pattern of circadian blood pressure rhythm
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DOI：
10.1016/j.mehy.2006.04.024
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发表时间：
2006-01-01
影响因子：
4.7
通讯作者：
Kimura, Genjiro
中科院分区：
文献类型：
--
作者：
Fukuda, Michio;Goto, Norihiko;Kimura, Genjiro
部分钠敏感型高血压或肾病患者夜间血压不降称为“不降”，夜间血压正常者称为“降”。许多研究人员报告说，不喝咖啡的人患心血管并发症的风险肯定更大。我们最近提出，除了长期的血压调节外，肾脏在决定血压的昼夜节律中起着重要的作用。当钠摄入量高时，肾脏排钠能力的缺陷变得明显，使夜间血压升高，即非降血压，以补偿白天减少的尿钠，增强夜间的尿钠压力。因此，当肾功能恶化时，夜间血压开始下降可能需要更长的时间。不浸渍可能是引起慢性肾脏疾病心血管事件的机制之一。(c) 2006 Elsevier Ltd.版权所有。
In some patients with sodium sensitive type of hypertension or kidney disease, blood pressure (BP) fails to dip during night and they have been called "non-dipper", whereas those with a normal nocturnal dip are called "dipper". Many investigators reported that non-dippers were certainly exposed to greater risks of cardiovascular complications. We have recently proposed that kidneys play an important rote in determining the circadian rhythm of BP, in addition to long-term BP regulation. When sodium intake is high, the defect in sodium excretory capability of kidneys becomes evident, making BP during night elevated, that is non-dipper, in order to compensate for diminished natriuresis during daytime and to enhance pressure-natriuresis during night. Therefore, as renal function deteriorates, longer duration may be required before BP begins to dip during night. Non-dipping may be one mechanism causing cardiovascular events in chronic kidney disease. (c) 2006 Elsevier Ltd. All rights reserved.