Transgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quail.
Transgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quail.
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DOI：
10.1038/srep46125
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发表时间：
2017-04-07
影响因子：
4.6
通讯作者：
Spencer KA
中科院分区：
文献类型：
--
作者：
Zimmer C;Larriva M;Boogert NJ;Spencer KA
发展规划的一个有趣的方面是跨代效应的存在，它影响后代的特征和以后的生活表现。据推测，这些跨代效应使个体能够更好地应对可预测的环境波动，从而促进对不断变化的环境的适应。在这里，我们首次使用全因子设计测试了早期生活压力如何驱动发育程序和母亲暴露于早期生活压力对其后代的几个表型性状在功能相关背景下的跨代效应。我们对日本鹌鹑母亲和后代进行了产前和/或产后压力处理，并检查了后代一代中几种与压力相关的特征的后果。我们发现，母亲所经历的产前压力不仅会影响后代的表型，还会导致后代在我们所研究的所有表型水平上遗传相同的压力应对特征，从而形成神经内分泌、生理和行为特征。这可能有助于母亲更好地为后代做好准备，以应对以后经历相同压力源的环境。
An interesting aspect of developmental programming is the existence of transgenerational effects that influence offspring characteristics and performance later in life. These transgenerational effects have been hypothesized to allow individuals to cope better with predictable environmental fluctuations and thus facilitate adaptation to changing environments. Here, we test for the first time how early-life stress drives developmental programming and transgenerational effects of maternal exposure to early-life stress on several phenotypic traits in their offspring in a functionally relevant context using a fully factorial design. We manipulated pre- and/or post-natal stress in both Japanese quail mothers and offspring and examined the consequences for several stress-related traits in the offspring generation. We show that pre-natal stress experienced by the mother did not simply affect offspring phenotype but resulted in the inheritance of the same stress-coping traits in the offspring across all phenotypic levels that we investigated, shaping neuroendocrine, physiological and behavioural traits. This may serve mothers to better prepare their offspring to cope with later environments where the same stressors are experienced.