Dynamics of depolarization and hyperpolarization in the frontal cortex and saccade goat
Dynamics of depolarization and hyperpolarization in the frontal cortex and saccade goat
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DOI：
10.1126/science.1066641
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发表时间：
2002-02-01
期刊：
影响因子：
56.9
通讯作者：
Slovin, H
中科院分区：
文献类型：
--
作者：
Seidemann, E;Arieli, A;Slovin, H
灵长类皮层的额叶视野和邻近区域 8Ar 参与眼跳的编程和执行。这些区域的电微刺激会引起短延迟的对侧眼跳。为了确定微刺激诱发活动的时空动态如何转化为眼跳计划，我们在行为猴子中结合使用了实时光学成像和微刺激。短暂的刺激序列引发了快速而广泛的去极化波，随后是意想不到的大规模且长期的超极化。在此超极化期间，眼跳几乎完全是同侧的，这表明超极化在确定眼跳目标中发挥着重要作用。
The frontal eye field and neighboring area 8Ar of the primate cortex are involved in programming and execution of saccades. Electrical microstimulation in these regions elicits short-latency contralateral saccades. To determine how spatiotemporal dynamics of microstimulation-evoked activity are converted into saccade plans, we used a combination of real-time optical imaging and microstimulation in behaving monkeys. Short stimulation trains evoked a rapid and widespread wave of depolarization followed by unexpected large and prolonged hyperpolarization. During this hyperpolarization saccades are almost exclusively ipsilateral, suggesting an important role for hyperpolarization in determining saccade goal.