Design, syntheses, and biological evaluations of squamostolide and its related analogs.
Design, syntheses, and biological evaluations of squamostolide and its related analogs.
复制标题
鳞蝽内酯及其相关类似物的设计、合成和生物学评价。
DOI：
10.1016/j.bmc.2005.05.050
复制
发表时间：
2005
影响因子：
3.5
通讯作者：
Ming
中科院分区：
文献类型：
--
作者：
C. Lee;Chi;W. Lin;Kunrui Wang;Ya;Shinne‐ren Lin;Yang;Ming
设计并合成了用于生物评价的鳞茎内酯及其类似物。所有这些化合物都被测试了对人类肿瘤细胞株的生长抑制活性，其中一种化合物对60种人类癌细胞株显示出最强的细胞毒性。同一化合物在流式细胞仪分析中也显示出G2/M期停滞和微弱的细胞凋亡作用。
Squamostolide and its related analogs were designed and synthesized for biological evaluation. All these compounds were tested for growth inhibition activities against human tumor cell lines, in which one of the compounds showed the most potent cytotoxicity among these derivatives against a full panel of 60 human cancer cell lines. The same compound also showed G2/M phase arrest and a weak apoptotic effect during flow cytometric analysis.
影响因子：
6.1
作者：
D. Morré;R. D. Cabo;Christopher Farley;N. Oberlies;Jerry L. McLaughlin
通讯作者：
D. Morré;R. D. Cabo;Christopher Farley;N. Oberlies;Jerry L. McLaughlin