High expression of cell division cycle 7 protein correlates with poor prognosis in patients with diffuse large B-cell lymphoma
High expression of cell division cycle 7 protein correlates with poor prognosis in patients with diffuse large B-cell lymphoma
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DOI：
10.1007/s12032-012-0223-y
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发表时间：
2012-12-01
期刊：
影响因子：
3.4
通讯作者：
Ba, Yi
中科院分区：
文献类型：
--
作者：
Hou, Yun;Wang, Hua-Qing;Ba, Yi
弥漫性大B细胞淋巴瘤（DLBCL）是最常见的淋巴瘤形式。根据临床危险因素和生物学异质性，DLBCL的临床结局差异极大，5年生存率在30%至80%之间。尽管国际预后指数（IPI）仍然是用于预测DLBCL患者结局的主要临床工具，但在相同的IPI评分中仍观察到结局的显著差异。细胞分裂周期7（CDC 7）是一种丝氨酸-苏氨酸激酶，它是启动DNA复制所必需的。研究表明，CDC 7的高表达与DLBCL患者的不良预后相关。CDC 7是否是DLBCL的独立预后因素仍有争议。我们用免疫组化方法研究了60例中国DLBCL患者中CDC 7蛋白的表达，其中34例（56.7%）为低表达，26例（43.3%）为高表达。CDC 7低表达组中位生存期未达到，而高表达组中位生存期为9个月（P = 0.027）。多因素分析显示IPI评分和安阿伯分期是影响患者OS的独立预后因素（P < 0.05）。Pearson相关分析显示，CDC 7表达水平与IPI评分、安阿伯分期呈正相关（P < 0.001）。结果提示CDC 7表达水平、IPI评分和安阿伯分期可作为DLBCL患者的特异性预后因素。CDC 7也可能是DLBCL的潜在治疗靶点，尤其是ABC-DLBCL。
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma. According to the clinical risk factors and biological heterogeneity, clinical outcome of DLBCL is extremely various, with 5-year survival rates between 30 and 80 %. Although the International Prognostic Index (IPI) remains the primary clinical tool used to predict outcome for patients with DLBCL, notable variability in outcome is still observed within the same IPI score. The cell division cycle 7 (CDC7) is a serine-threonine kinase, which is required to initiate DNA replication. Study showed that high expression of CDC7 was correlated with poor prognosis in patients with DLBCL. Whether CDC7 is an independent prognostic factor for DLBCL remains debatable. We studied the expression of CDC7 protein in 60 Chinese DLBCL patients with immunohistochemical analysis, 34 patients (56.7 %) categorized as low CDC7 expression and 26 patients (43.3 %) as high CDC7 expression. The median survival time of patients with low CDC7 expression was not achieved and that of high expression was 9 months (P = 0.027). A multivariate analysis showed that IPI score and Ann Arbor stage were independent prognostic factors in relation to patients' OS (P < 0.05). Pearson correlation analysis showed that CDC7 expression level was positively correlated with IPI score and Ann Arbor stage (P < 0.001). The results suggest that CDC7 expression level in combination with IPI score and Ann Arbor stage can be specific prognostic factors for DLBCL patients. CDC7 could also be a potential therapeutic target in DLBCL, especially for ABC-DLBCL.