ACUTE REDUCTION IN EXTRACELLLULAR FLUID VOLUME AND CONCENTRATION OF ANTIDIURETIC HORMONE IN BLOOD
ACUTE REDUCTION IN EXTRACELLLULAR FLUID VOLUME AND CONCENTRATION OF ANTIDIURETIC HORMONE IN BLOOD
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DOI：
10.1210/endo-69-5-925
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发表时间：
1961-01-01
期刊：
影响因子：
4.8
通讯作者：
SHARE, L
中科院分区：
文献类型：
--
作者：
SHARE, L
本文应用一种新的化学方法提取和纯化血液抗利尿激素（ADH），研究了细胞外液减少对狗ADH释放的影响。通过用高渗溶液腹腔灌洗减少细胞外液量。该高渗溶液的电解质组成与组织液相似，葡萄糖浓度为10%。灌洗开始后20分钟，颈静脉血中ADH的浓度增加了6倍。此时，细胞外液体积仅相对较小地减少。由于灌洗液中葡萄糖的流入，血浆渗透压增加了4%。然而，ADH的血药浓度升高显然不是血浆渗透压升高的结果。当血浆渗透压升高到一个类似的程度，通过静脉输注的浓缩葡萄糖溶液，在颈静脉血中的ADH浓度不受影响。因此，可以得出结论，细胞外液量的急性减少导致神经垂体系统释放ADH增加。
A new chemical method for the extraction and purification of blood antidiuretic hormone (ADH) has been applied to the study of the effect of a reduction in extracellular fluid volume on the release of ADH in the dog. The extracellular fluid volume was reduced by peritoneal lavage with a hypertonic solution. This hypertonic solution had an electrolyte composition similar to that of interstitial fluid and a glucose concentration of 10%. Twenty minutes after the start of lavage the concentration of ADH in jugular vein blood had increased six-fold. At this time there was only a relatively small reduction in extracellular fluid volume. The plasma osmolality was increased by 4% as the result of an influx of glucose from the lavage solution. However, the increased blood concentration of ADH was apparently not the result of the increased plasma osmolality. When the plasma osmolality was elevated to a similar extent by the intravenous infusion of a concentrated glucose solution, the concentration of ADH in jugular vein blood was not affected. Thus, it is concluded that acute reduction in extracellular fluid volume results in increased release of ADH by the neurohypophyseal system.