Regional Cerebral Blood Flow and Metabolism in Vivo: Effects of Anoxia, Hypoglycemia, Ischemia, Acidosis, Alkalosis, and Alterations of Blood PCO2
Regional Cerebral Blood Flow and Metabolism in Vivo: Effects of Anoxia, Hypoglycemia, Ischemia, Acidosis, Alkalosis, and Alterations of Blood PCO2
复制标题
体内局部脑血流量和代谢：缺氧、低血糖、缺血、酸中毒、碱中毒和血液 PCO2 变化的影响
DOI：
10.1001/archneur.1962.04210060078006
复制
发表时间：
1962
期刊：
影响因子：
29
通讯作者：
L. Symon
中科院分区：
文献类型：
--
作者：
J. Meyer;F. Gotoh;Y. Tazaki;K. Hamaguchi;S. Ishikawa;F. Nouailhat;L. Symon
方法实验在大型恒温实验室中进行。使用了超过68只猴（猕猴和食蟹猴）和2只猫。动物禁食并准备乙醚麻醉。制备示意图见图1。暴露并结扎左颈内静脉。将两种长度的聚乙烯导管（PE 160或205）插入静脉的头端和心端，并用丝线牢固地绑住。在一些实验中，通过矢状窦将穿孔导管插入到窦汇。完成所有手术后，将导管连接至电极歧管和血泵（见下文）。在两个颈动脉周围放置松散的结扎线，并且在一些实验中，在两个椎动脉周围放置松散的结扎线，使得它们可以在实验期间暂时闭塞。插入气管导管并连接
Methods The experiments to be described were carried out in a large laboratory maintained at constant temperature. Over 68 monkeys (Macacca rhesus and cynomolgus) and 2 cats were used. The animals were fasted and prepared with ether anesthesia. A diagram of the preparation is shown in Figure 1. The left internal jugular vein was exposed and ligated. Two lengths of polyethylene catheter (PE 160 or 205) were inserted into the cephalic and cardiac ends of the vein and securely tied with silk ligatures. In some experiments a perforated catheter was inserted via the sagittal sinus to the torcular. After all surgery was completed, the catheters were connected to the electrode manifold and blood pump to be described. Loose ligatures were placed around both carotid arteries and, in some experiments, both vertebral arteries so that they could be temporarily occluded during the experiment. A tracheal catheter was inserted and was connected