Diastereoselective synthesis of pentasubstituted gamma-butyrolactones from silyl glyoxylates and ketones through a double Reformatsky reaction.
Diastereoselective synthesis of pentasubstituted gamma-butyrolactones from silyl glyoxylates and ketones through a double Reformatsky reaction.
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DOI：
10.1002/anie.200900215
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发表时间：
2009
影响因子：
16.6
通讯作者：
Johnson, Jeffrey S.
中科院分区：
文献类型：
--
作者：
Greszler, Stephen N.;Johnson, Jeffrey S.
Three contiguous stereocenterscan be established with remarkable diastereoselectivity in a double Reformatsky sequence. Densely functionalized γ‐butyrolactones were assembled rapidly by this approach, in which a ketone is used as the terminal electrophile (see scheme). Secondary transformations of the lactone products enhance their synthetic utility. R1=Me, H; R2=alkyl, aryl, CF3; Bn=benzyl, TBS=tert‐butyldimethylsilyl.
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