Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer.
Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer.
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DOI：
10.1002/lary.25290
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Hecht SS
中科院分区：
文献类型：
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作者：
Khariwala SS;Carmella SG;Stepanov I;Bandyopadhyay D;Nelson HH;Yueh B;Hatsukami DK;Hecht SS
头颈部鳞状细胞癌（HNSCC）与烟草使用密切相关。我们试图在一组HNSCC患者中研究自我报告的烟草使用与尿液烟草致癌代谢物水平之间的关系。横截面分析。84名吸烟的头颈癌患者完成了烟草和酒精使用问卷，并定量了以下尿液烟草代谢物：1-羟基芘（1-HOP）、N ′-亚硝基去甲烟碱及其葡萄糖醛酸苷（总NNN）、4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁醇及其葡萄糖醛酸苷（总NNAL）和可替宁。进行横断面分析，评估相关系数。当基于自我报告的每日吸烟量（CPD）进行分析时，未发现与任何研究的烟草致癌物代谢产物的显著相关性。然而，尿可替宁与总NNN、总NNAL和1-HOP显著相关。总NNN、总NNAL和1-HOP显示彼此显著相关，表明暴露量按比例发生。在患有HNSCC的吸烟者中，自我报告的烟草使用并不能预测实际的致癌物暴露。相反，尿可替宁水平与致癌物水平显著相关。因此，尿可替宁是估计这些患者致癌物剂量的首选值。1-HOP水平与总NNN和总NNAL显著相关，表明吸烟者按比例暴露于这些致癌物。这些数据表明，利用传统的方法估计烟草暴露（CPD）可能无法准确估计吸烟者HNSCC的烟草致癌物暴露。这些数据对未来的研究具有重要意义，这些研究重点是HNSCC吸烟者的筛查和流行病学。na
Head and neck squamous cell carcinoma (HNSCC) is strongly associated with tobacco use. We sought to examine the relationship between self-reported tobacco use and the level of urinary tobacco carcinogen metabolites in a cohort of patients with HNSCC. Cross-sectional analysis. Eighty-four cigarette smokers with head and neck cancer completed tobacco and alcohol use questionnaires, and the following urinary tobacco metabolites were quantified: 1-hydroxypyrene (1-HOP), N′-nitrosonornicotine and its glucuronides (total NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), and cotinine. A cross-sectional analysis was performed with assessment of correlation coefficients. When analyzed based on self-reported cigarettes per day (CPD), no significant correlation with any of the studied tobacco carcinogen metabolites was found. However, urinary cotinine showed significant correlation with total NNN, total NNAL, and 1-HOP. Total NNN, total NNAL, and 1-HOP showed significant correlation with each other suggesting exposure occurs to each proportionally. In smokers with HNSCC, self-reported tobacco use does not predict actual carcinogen exposure. In contrast, urinary cotinine levels significantly correlate with carcinogen levels. Therefore, urinary cotinine is the preferred value for estimating carcinogen dose in these patients. 1-HOP levels were significantly associated with total NNN and total NNAL suggesting that smokers are exposed to these carcinogens proportionally. These data indicate that utilizing conventional methods of estimating tobacco exposure (CPD) may not accurately approximate exposure to tobacco carcinogens in smokers with HNSCC. These data have implications for future studies focused on screening and epidemiology of smokers with HNSCC. NA