Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake.
Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake.
复制标题
合成 3-芳基爱康宁类似物作为可卡因结合和多巴胺摄取的抑制剂。
DOI：
10.1021/jm00169a036
复制
发表时间：
1990
影响因子：
7.3
通讯作者：
Eldefrawi,ME
中科院分区：
文献类型：
--
作者：
KlineJr,RH;Wright,J;Fox,KM;Eldefrawi,ME
Cocaine abuse has become a serious social problemin the US 1 Initially believed to be nonaddictive, it is now accepted that cocaine is an additive drug. 2 Addiction to cocaine is driven by the powerful positive reinforcing properties of the drug. 3 4There is strong evidence that the mesocorticolimbic dopamine (DA) system of the brain is the target site for cocaine and possibly other addictive drugs. 4-7 Cocaine (1) inhibits uptake of DA into thedo-
