CORRELATION OF HOST IMMUNE-RESPONSE WITH QUANTITATIVE RECOVERY OF CHLAMYDIA-TRACHOMATIS FROM THE HUMAN ENDOCERVIX
CORRELATION OF HOST IMMUNE-RESPONSE WITH QUANTITATIVE RECOVERY OF CHLAMYDIA-TRACHOMATIS FROM THE HUMAN ENDOCERVIX
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DOI：
10.1128/iai.39.3.1491-1494.1983
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发表时间：
1983-01-01
影响因子：
3.1
通讯作者：
HOLMES, KK
中科院分区：
文献类型：
--
作者：
BRUNHAM, RC;KUO, CC;HOLMES, KK
我们对95例无并发症的沙眼衣原体宫颈感染妇女进行了研究。在HeLa 229细胞中进行沙眼衣原体的定量分离，并与血清免疫球蛋白M和免疫球蛋白G抗体进行相关分析。我们发现，沙眼衣原体的定量培养可以提供一个有意义的测量方法，通过它来评估获得性免疫反应的效果。特别是，宫颈分泌物中抗沙眼衣原体的分泌性免疫球蛋白A抗体与宫颈有机体的恢复呈显著的负相关。这提示免疫反应中的这一部分可能调节机体的脱落。
We studied 95 women with uncomplicated Chlamydia trachomatis cervical infection. Quantitative isolation of C. trachomatis was performed in HeLa 229 cells, and the results were correlated with serum immunoglobulin M and immunoglobulin G antibody to the organism. We found that quantitative cultures for C. trachomatis can provide a meaningful measurement by which to evaluate the effect of the acquired immune response. In particular, secretory immunoglobulin A antibody to C. trachomatis in cervical secretion demonstrated a striking and inverse correlation with recovery of the organism from the cervix. It is suggested that this component of the immune response may regulate shedding of the organism.