Plasma testosterone binding globulin and indexes of the concentration of unbound plasma androgens in normal and hirsute subjects.
Plasma testosterone binding globulin and indexes of the concentration of unbound plasma androgens in normal and hirsute subjects.
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正常和多毛受试者的血浆睾酮结合球蛋白和未结合血浆雄激素浓度指数。
DOI：
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发表时间：
1971
影响因子：
5.8
通讯作者：
R. L. Rosenfield
中科院分区：
文献类型：
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作者：
R. L. Rosenfield
本文研究了血浆游离雄激素水平与性毛类型的关系。探讨了多毛妇女血浆游离雄激素水平可能因睾酮和其他17β-羟基类固醇浓度升高或“睾酮结合球蛋白”（TeBG）降低而升高的可能性。非睾酮17β-羟基类固醇具有潜在的雄激素性，无论是固有的还是通过其从结合位点取代睾酮的能力。游离血浆睾酮浓度的指数计算为总浓度与通过活性炭吸收技术在稀释血浆中测定的TeBG中游离睾酮-3H的百分比的乘积。从17 β-羟基类固醇与TeBG的总浓度和结合百分比获得游离血浆17β-羟基类固醇3和TeBG滴度（表示为睾酮结合能力）的指数。游离睾酮和17β-羟类固醇指数在儿童、女性、多毛女性和男性中显著增高。
ABSTRACT The relation of plasma free androgen levels to the pattern of sexual hair was studied. The possibility was explored that plasma free androgen levels in hirsute women might be increased by elevated concentrations of testosterone and other 17β-hydroxysteroids or by low “testosterone binding globulin” (TeBG). Nontestosterone 17β-hydroxysteroids are potentially androgenic, either inherently or by their ability to displace testosterone from binding sites. An index of the free plasma testosterone concentration was calculated as the product of the total concentration and the percentage of testosterone-3H free from TeBG as determined in diluted plasma by a charcoal absorption technique. An index of the free plasma 17β-hydroxysteroids3 and titer of TeBG (expressed as testosterone binding capacity) was obtained from the total concentration and percentage binding of 17β-hydroxysteroids to TeBG. Free testosterone and 17β-hydroxysteroid indexes were succesively higher in children, females, hirsute females and...