Susceptibility to and resistance determinants of fusidic acid in Staphylococcus aureus isolated from Chinese children with skin and soft tissue infections
Susceptibility to and resistance determinants of fusidic acid in Staphylococcus aureus isolated from Chinese children with skin and soft tissue infections
复制标题
中国皮肤软组织感染儿童金黄色葡萄球菌对夫西地酸的敏感性和耐药性决定因素。
DOI：
10.1111/j.1574-695x.2011.00887.x
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发表时间：
2012-03-01
影响因子：
--
通讯作者：
Shen, Xuzhuang
中科院分区：
文献类型：
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作者：
Liu, Yingchao;Geng, Wenjing;Shen, Xuzhuang
本研究旨在确定从中国儿童皮肤和软组织感染（SSTI）患者中收集的金黄色葡萄球菌分离株中夫西地酸的耐药率和决定因素。 2008年至2009年间，从儿童SSTI患者中总共收集了186株临床分离的金黄色葡萄球菌，其中脓肿（44.6%）是16岁儿童中最常见的SSTI。四种临床分离株（4/186，2.2%）对夫西地酸耐药。其中两个分离株是携带fusC基因的耐甲氧西林金黄色葡萄球菌（MRSA）。另外两个分离株是携带fusB 基因的甲氧西林敏感金黄色葡萄球菌（MSSA）。在两个fusB阳性临床分离株中，fusB基因位于转座子样元件中，与来自金黄色葡萄球菌的pUB101片段具有99%的同一性。四种耐夫西地酸的临床分离株为 ST1-MRSA-SCCmecV-t127、ST93-MRSA-SCCmecIII-t202、ST680-MSSA-t5415 和 ST680-MSSA-t377。中国儿童SSTI患者分离的金黄色葡萄球菌对夫西地酸耐药率较低，fusB和fusC基因是主要耐药决定因素。含有fusB基因的转座子样元件可能参与夫西地酸抗性基因的传递。这是中国大陆首次出现耐夫西地酸临床金黄色葡萄球菌分离株的报道。
This study aims to determine the resistance rates and determinants of fusidic acid among Staphylococcus aureus isolates collected from Chinese pediatric patients with skin and soft tissue infections (SSTIs). Between 2008 and 2009, a total of 186 clinical S. aureus isolates were collected from the pediatric patients with SSTIs, abscess (44.6%) was the most common SSTI in children 016 years old. Four clinical isolates (4/186, 2.2%) were resistant to fusidic acid. Two of these isolates were methicillin-resistant S. aureus (MRSA) that carry the fusC gene. The other two isolates were methicillin-sensitive S. aureus (MSSA) that carry the fusB gene. In the two fusB-positive clinical isolates, the fusB gene was located in a transposon-like element that has 99% identity with a pUB101 fragment from S. aureus. The four fusidic acid-resistant clinical isolates were ST1-MRSA-SCCmecV-t127, ST93-MRSA-SCCmecIII-t202, ST680-MSSA-t5415, and ST680-MSSA-t377. The fusidic acid resistance rate of S. aureus isolated from Chinese pediatric patients with SSTIs was low, and the genes fusB and fusC were the main resistance determinants. The transposon-like element that contains the fusB gene might participate in the transmission of fusidic acid resistance genes. This is the first report regarding the emergence of fusidic acid-resistant clinical S. aureus isolates in mainland China.