Bronchial reactivity to prostaglandins F2alpha, E2, and histamine in different types of asthma.
Bronchial reactivity to prostaglandins F2alpha, E2, and histamine in different types of asthma.
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不同类型哮喘的支气管对前列腺素 F2α、E2 和组胺的反应性。
DOI：
10.1159/000193844
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
R. Niżankowski
中科院分区：
文献类型：
--
作者：
A. Szczeklik;E. Niżankowska;R. Niżankowski
对27例阿司匹林敏感型哮喘患者和28例非阿司匹林敏感型哮喘患者的支气管对前列腺素F2pha(PGF2pha)、E2(PGE2)和组胺的反应性进行了研究。后者中特应性哮喘13例，感染性哮喘9例，混合型哮喘6例。特应性患者的特点是对低剂量的PGF2α和组胺都有明显的反应。在感染性哮喘患者中，与特应性药物相比，需要更高剂量的PGF2pha和组胺来诱导支气管收缩。对阿司匹林敏感的患者对与阿托品相似剂量的组胺反应迅速，但耐受剂量明显更高的PGF2pha。阿司匹林敏感患者和感染性哮喘患者对PGF2α的反应性无差异。服用60微克前列腺素E_2 5分钟和10分钟后，阿司匹林敏感患者的换气改善明显好于特应性或感染性患者。结果表明，不同类型的哮喘及其症状的严重程度不同，对前列腺素和组胺的支气管反应性也不同。
Bronchial reactivity to prostaglandins F2alpha (PGF2alpha), E2 (PGE2) and histamine has been studied in 27 patients with aspirin-sensitive asthma and in 28 asthmatics without this sensitivity. Of the latter group, 13 patients had atopic, 9 infectious, and 6 mixed type of asthma. Atopic patients were characterized by vivid reactivity to low doses of both PGF2alpha and histamine. In patients with infectious asthma significantly higher doses of both PGF2alpha and histamine were necessary to induce bronchoconstriction as compared to atopics. Aspirin-sensitive patients responded quickly with bronchial spasm to similar doses of histamine as atopics, but tolerated significantly higher doses of PGF2alpha. There was no difference in reactivity to PGF2alpha between patients with aspirin sensitivity and those with infectious asthma. 5 and 10 min after administration of 60 microgram PGE2 significantly better improvement in ventilation occurred in aspirin-sensitive patients than in those of either atopic or infectious groups. The results obtained point to differences in bronchial reactivity to prostaglandins and histamine depending on type of asthma and severity of its symptoms.