Dermatologic manifestations of Lyme disease.
Dermatologic manifestations of Lyme disease.
复制标题
莱姆病的皮肤病表现。
DOI：
--
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
B. W. Berger
中科院分区：
文献类型：
--
作者：
B. W. Berger
Erythema migrams (EM), the distinctive cutaneous lesion of Lyme disease, has a variable clinical appearance, but at some point presents as a centrifugally expanding, usually erythematous, annular patch. Of 237 patients with this condition, 201 (85%) were examined initially from May through September. Thirty-four (14%) remembered having been bitten by a deer tick. The median interval from the bite to the appearance of EM was 9 days (range, 1-36 days). Forty-one (17%) of the patients had multiple EM lesions. Of the 237 patients, 128 (54%) manifested major extracutaneous signs and symptoms. Although EM also has a variable histologic picture, the presence of a deep and superficial perivascular and interstitial lymphohistiocytic infiltrate containing plasma cells is diagnostic. Spirochetes can be demonstrated with Warthin-Starry staining in approximately 40% of the biopsy specimens. Concomitant cutaneous lesions appeared on some patients before and during antibiotic therapy. Nine patients with serologic evidence of Borrelia burgdorferi infection had cutaneous lesions other than EM, including granuloma annulare (three), erythema nodosum (two), papular urticaria (two), Henoch-Schönlein-like purpura (one), and morphea (one). Whether these entities are cutaneous markers of Lyme disease or are coincidental findings is yet to be determined.
影响因子：
39.2
作者：
Steere,AC;Hutchinson,GJ;Rahn,DW;Sigal,LH;Craft,JE;DeSanna,ET;Malawista,SE
通讯作者：
Malawista,SE
诊断早期莱姆病。
DOI：
10.1016/0002-9343(85)90432-2
发表时间：
1985
期刊：
The American journal of medicine
影响因子：
--
作者：
Shrestha,M;Grodzicki,RL;Steere,AC
通讯作者：
Steere,AC