Possible protective effect of milk, meat and fish for cerebrovascular disease mortality in Japan.
Possible protective effect of milk, meat and fish for cerebrovascular disease mortality in Japan.
复制标题
牛奶、肉类和鱼类对日本脑血管疾病死亡率的可能保护作用。
作者：
Y. Kinjo;V. Beral;Suminori Akiba;T. Key;Shoichi Mizuno;Paul N. Appleby;Naohito Yamaguchi;Shaw Watanabe;R. Doll
从1955年到1980年，脑血管疾病是日本的主要死亡原因。近几十年来，这种疾病的死亡率急剧下降。这种下降趋势似乎与日本人的饮食习惯相符。对日本一项大型前瞻性队列研究的数据进行分析，以检验饮食习惯与脑血管疾病死亡率之间的关系。这项分析的对象是223,170名年龄在40到69岁之间的男性和女性，以1965年12月为基准。在1966年1月至1981年12月的随访期间，有6 168名男性和4 862名女性死于脑血管疾病（ICD7: 330-334）。采用经性别、年龄、随访期、地区、吸烟、饮酒和职业调整后的比率比（RR）和95%置信区间（95% CI）进行比较。在这项研究中，脑血管疾病死亡的风险与乳制品、牛奶、肉类和鱼类的消费呈负相关。因此，乳、奶、肉和鱼（DMF）作为动物脂肪和蛋白质的联合效应引起了人们的兴趣。在二元分析中，DMF （D， M， F）是指乳制品（1-3次/周或以上）、肉类（1-3次/周或以上）和鱼类（4次/周或以上）的组合。因此，DMF （d, m, f）是奶制品（少于1次/周）、肉类（少于1次/周）和鱼类（少于4次/周）的参照组。对于该疾病，DMF （D， M， F）相对于对照组的RR为0.68,95% CI为0.63 ~ 0.74。此外，DMF的联合作用与脑出血的相关性更强(ICD7: 331, DMF (D， M， F)；RR: 0.63, 95% CI: 0.55-0.70)比脑栓塞和血栓形成(ICD7: 332, DMF (D， M， F)；Rr: 0.79, 95% ci: 0.70-0.89)。这些发现表明，增加动物脂肪和/或蛋白质的摄入量可能在减少日本脑血管疾病方面发挥了关键作用。
Cerebrovascular disease was a leading cause of death from 1955 to 1980 in Japan. The mortality rate from this disease has decreased sharply in recent decades. This downward trend seems to correspond to the dietary habits of Japanese. Data from a large prospective cohort study were analyzed to examine the association between dietary habits and cerebrovascular disease mortality in Japan. The subjects for this analysis were 223,170 men and women aged 40 to 69 at baseline in December 1965. There were 6,168 deaths in men and 4,862 deaths in women due to cerebrovascular disease (ICD7: 330-334) during the follow-up period from January 1966 to December 1981. Rate ratio (RR) and 95% confidence interval (95% CI) adjusted for sex, attained age, follow-up period, prefecture, cigarette smoking, alcohol drinking and occupation was used for comparison. In this study, the risk of mortality from cerebrovascular disease was inversely associated with dairy milk, meat and fish consumption. Therefore the joint effect of dairy milk, meat and fish (DMF) as animal fat and protein was of interest. In the binary analysis, DMF (D, M, F) means the combination of dairy milk (1-3 times/week or more), meat (1-3 times/week or more) and fish (4 times/week or more). Thus DMF (d, m, f) was the reference group having dairy milk (less than 1 time/week), meat (less than 1 time/week) and fish (less than 4 times/week). For the disease, the RR of DMF (D, M, F) was 0.68 with 95% CI of 0.63 to 0.74, relative to the reference group. Furthermore the joint effect of DMF was more strongly associated with cerebral haemorrhage (ICD7: 331, DMF (D, M, F); RR: 0.63, 95% CI: 0.55-0.70) than with cerebral embolism and thrombosis (ICD7: 332, DMF (D, M, F); RR: 0.79, 95% CI: 0.70-0.89). These findings suggest that the increasing intake of animal fat and/or protein may have played a key role in reducing cerebrovascular disease in Japan.
DOI：
10.1001/jama.1997.03550240035030
发表时间：
1997-12
期刊：
JAMA
影响因子：
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作者：
M. Gillman;L. Cupples;B. Millen;R. Ellison;P. Wolf
通讯作者：
M. Gillman;L. Cupples;B. Millen;R. Ellison;P. Wolf