PROSPECTIVE, RANDOMIZED TRIAL COMPARING A NEW SODIUM PHOSPHATE-BISACODYL REGIMEN WITH CONVENTIONAL PEG-ES LAVAGE FOR OUTPATIENT COLONOSCOPY PREPARATION
PROSPECTIVE, RANDOMIZED TRIAL COMPARING A NEW SODIUM PHOSPHATE-BISACODYL REGIMEN WITH CONVENTIONAL PEG-ES LAVAGE FOR OUTPATIENT COLONOSCOPY PREPARATION
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DOI：
10.1016/s0016-5107(05)80008-2
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发表时间：
1995-05-01
影响因子：
7.7
通讯作者：
MARSHALL, JB
中科院分区：
文献类型：
--
作者：
AFRIDI, SA;BARTHEL, JS;MARSHALL, JB
背景：最近的几项试验表明，使用磷酸钠溶液进行结肠镜检查准备与传统 PEG-ES 灌洗一样有效，并且至少具有良好的耐受性。这些试验使用了两次 1.5 液体盎司剂量，一次在结肠镜检查前一天晚上给药，另一次在第二天清晨给药。 方法：我们设计了一种新的磷酸钠治疗方案，其中整个剂量在检查前一天晚上给药（下午 4 点 1.5 液量盎司、下午 7 点 1.5 液量盎司、晚上 10 点 10 毫克比沙可啶），并进行了一项前瞻性随机试验，将其与传统 PEG-ES 灌洗进行比较在肾功能正常的门诊结肠镜检查人群中，结肠清洁的质量、患者耐受性和安全性方面。 72 名患者接受磷酸钠比沙可啶和 75 PEG-ES 灌洗。结果：两种方法的结肠清洁总体质量和不满意制剂的频率相似。患者发现用磷酸钠-比沙可啶进行准备比 PEG-ES 灌洗更容易 (p = 0.005)。两种制备方法均未发现临床上重要的副作用。磷酸比沙可啶钠的平均成本为每位患者 4.32 美元，而 PEG-ES 灌洗制剂的平均成本为 18.15 美元。 结论：在结肠镜检查前一天晚上给予磷酸比沙可啶钠制剂，是传统 PEG-ES 灌洗的一种耐受性良好、有效且经济高效的替代方案。
Background: Several recent trials have shown that colonoscopy preparation with sodium phosphate solution is as effective and at least as well tolerated as conventional PEG-ES lavage. These trials utilized two 1.5-fluid oz doses, one given on the evening before colonoscopy and the other early the next morning.Methods: We devised a new sodium phosphate regimen in which the entire dose was given on the evening before examination (1.5 fl oz at 4 PM, 1.5-fl oz at 7 PM and 10 mg of bisacodyl at 10 PM) and performed a prospective, randomized trial that compared it with conventional PEG-ES lavage in terms of quality of colon cleansing, patient tolerance, and safety in an outpatient colonoscopy population with normal renal function. Seventy-two patients received sodium phosphate-bisacodyl and 75 PEG-ES lavage.Results: The overall quality of colon cleansing and frequency of unsatisfactory preparations were similar with both methods. Patients found preparation with sodium phosphate-bisacodyl to be easier than PEG-ES lavage (p = 0.005). No clinically important adverse effects were seen with either method of preparation. The average cost of sodium phosphate-bisacodyl was $4.32 per patient compared with $18.15 for PEG-ES lavage preparation.Conclusion: Preparation with sodium phosphate-bisacodyl, given on the evening before colonoscopy, is a well-tolerated, efficacious, and cost-effective alternative to conventional PEG-ES lavage.