THE INFLUENCE OF PITUITARY-HORMONES ON ADJUVANT ARTHRITIS
THE INFLUENCE OF PITUITARY-HORMONES ON ADJUVANT ARTHRITIS
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DOI：
10.1002/art.1780270612
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
KOVACS, K
中科院分区：
文献类型：
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作者：
BERCZI, I;NAGY, E;KOVACS, K
在雌性Fisher大鼠的右后爪注射0.1 ml弗氏完全佐剂诱导佐剂性关节炎。佐剂性关节炎的发展受到抑制垂体切除术和每日治疗的完整的动物与多巴胺能药物溴隐亭。如果垂体切除或溴隐亭抑制动物接受催乳素或生长激素治疗，则佐剂性关节炎正常发生。ACTH的额外治疗抑制了这种恢复。用FSH、促黄体生成素和TSH治疗垂体切除大鼠没有效果。催乳素和/或生长激素显然是佐剂性关节炎发展所必需的，而促肾上腺皮质激素具有抑制作用。
Adjuvant arthritis was induced in female Fisher rats by injecting their right hind paw with 0.1 ml Freund''s complete adjuvant. The development of adjuvant arthritis was inhibited by hypophysectomy and by daily treatment of intact animals with the dopaminergic agent bromocriptine. Adjuvant arthritis developed normally if hypophysectomized or bromocriptine-suppressed animals were treated with either prolactin or growth hormone. Additional treatment with ACTH inhibited this restoration. Treatment of hypophysectomized rats with FSH, luteinizing hormone and TSH had no effect. Prolactin and/or growth hormone evidently are necessary for the development of adjuvant arthritis, whereas adrenocorticotropic hormone has an inhibitory effect.