Cortical and subcortical changes in patients with premenstrual syndrome
Cortical and subcortical changes in patients with premenstrual syndrome
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经前综合症患者的皮质和皮质下变化
DOI：
10.1016/j.jad.2018.04.046
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发表时间：
2018
影响因子：
6.6
通讯作者：
Qin Wei
中科院分区：
文献类型：
--
作者：
Liu Peng;Wei Ying;Fan Yingying;Liao Hai;Wang Geliang;Li Ru;Duan Gaoxiong;Deng Demao;Qin Wei
经前综合征（PMS）以一系列情绪、身体和行为症状为特征。经前症候群虽与中枢神经系统功能障碍有关，但其神经病理机制尚未明确。本研究的目的是评估经前症候群患者与健康对照（hc）相比皮质厚度和皮质下体积的潜在差异。方法对20例经前综合征患者和20例hc患者进行结构磁共振成像扫描和临床评价。使用FreeSurfer图像分析套件计算皮质厚度和皮质下体积。然后在患者中测量皮质厚度/皮质下体积与每日问题严重程度评分（DRSP）之间的关系。结果PMS患者内侧前额叶皮质（MPFC）、眶额叶皮质（OFC）和脑岛皮质厚度减少，杏仁核、丘脑和白脑皮质下体积增加。此外，DRSP与前扣带皮层和楔前叶皮质厚度呈负相关。局限性：本研究样本量小，参与者年龄范围窄。结论经前症候群患者的异常形态学变化主要与情绪调节和内脏知觉有关。我们希望我们的研究可以有助于更好地了解经前症候群。
BackgroundPremenstrual syndrome (PMS) is characterized by a series of emotional, physical and behavioral symptoms. Although PMS is related to dysfunctions of the central nervous system, the neuropathological mechanism of PMS still has not been clearly established. The aim of this study is to evaluate potential differences in both cortical thickness and subcortical volumes in PMS patients compared to healthy controls (HCs).MethodsTwenty PMS patients and twenty HCs underwent a structural magnetic resonance imaging scan and clinical assessment. Cortical thickness and subcortical volumes were computed using the FreeSurfer image analysis suite. Relationships between cortical thickness/subcortical volumes and the daily rating of severity of problems (DRSP) score were then measured in patients.ResultsCompared to HCs, PMS patients exhibited reduced cortical thickness in the medial prefrontal cortex (MPFC), orbitofrontal cortex (OFC) and insula, and increased subcortical volumes of the amygdala, thalamus and pallidum. Furthermore, negative correlations were detected between the DRSP and cortical thickness in the anterior cingulate cortex and precuneus.LimitationsThe study is limited by a small sample size and narrow age range of participants.ConclusionsOur findings indicate that the abnormal morphological changes are mainly implicated in emotional regulation and visceral perception in PMS patients. We hope that our study may contribute to a better understanding of PMS.