The Characteristics of the Transitional Zone in Prostate Growth With Age
The Characteristics of the Transitional Zone in Prostate Growth With Age
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前列腺随年龄生长的移行区特点
DOI：
10.1016/j.urology.2017.03.010
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发表时间：
2017-07-01
期刊：
影响因子：
2.1
通讯作者：
Hu, Bing
中科院分区：
文献类型：
--
作者：
Cao, Nailong;Lu, Qijie;Hu, Bing
目的探讨经直肠超声测量前列腺参数的年龄相关性变化，同时评价不同体积的移行带测量结果。方法对2001年在上海交通大学附属第六人民医院门诊就诊的良性前列腺增生症(BPH)合并前列腺炎患者进行回顾性研究。所有受试者均接受国际前列腺症状评分和经直肠前列腺超声检查。结果前列腺体积、指数、移行带长度和宽度与年龄增长关系最为密切。值得注意的是，过渡区的测量结果显示，50岁以上的个体之间存在显著差异。此外，前列腺参数增长速度最快的年龄在50岁至69岁之间。此外，我们还发现移行带参数和不同前列腺体积之间的差异随着年龄的增长而不同。结论移行带增长是前列腺总增长的主要贡献因素，特别是在50~69岁年龄段，这可能解释了BPH下尿路症状的高发生率。鉴于移行区的速度和前列腺总体积水平的增加，需要进一步的研究来确定这种差异的潜在机制。(C)2017年爱思唯尔公司。
OBJECTIVE To investigate the age-related growth variation in prostatic parameters by transrectal ultrasound with a simultaneous evaluation of the transitional zone measurements in different prostate volumes.METHODS A retrospective study of 2001 subjects derived from the outpatient clinic at our institution (Shanghai Jiao Tong University Affiliated Sixth People's Hospital in Shanghai) who were diagnosed with benign prostatic hyperplasia (BPH) and prostatitis was reviewed. All subjects were evaluated by the International Prostatic Symptom Score and transrectal ultrasound of the prostate. Statistical analysis was conducted between prostatic parameters and age.RESULTS The prostate volume, index, length, and width of transitional zone were the parameters most closely associated with increasing age. Notably, the transitional zone measurements showed a significant difference among individuals greater than 50 years old. Moreover, the fastest increasing rate of prostatic parameters was found to be between the ages of 50 and 69. Additionally, we also discovered that the difference between transitional zone parameters and different prostate volumes varies along with increasing age.CONCLUSION These results suggest that transitional zone growth is the main contributor to total prostate growth, especially at the ages of 50-69, which may elucidate the higher incidence of the lower urinary tract symptoms from BPH. In view of the increasing rate of transitional zone and the level of total prostate volume, further research is needed to identify the underlying mechanism for such differences in prostate growth. (C) 2017 Elsevier Inc.