Does Fetal Exposure to SSRIs or Maternal Depression Impact Infant Growth?
Does Fetal Exposure to SSRIs or Maternal Depression Impact Infant Growth?
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DOI：
10.1176/appi.ajp.2012.11121873
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发表时间：
2013-05-01
影响因子：
17.7
通讯作者：
Wisniewski, Stephen W.
中科院分区：
文献类型：
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作者：
Wisner, Katherine L.;Bogen, Debra L.;Wisniewski, Stephen W.
目的：本研究的目的是比较产前重度抑郁症妇女所生婴儿的生长情况，无论是未经治疗还是使用选择性5 -羟色胺再摄取抑制剂（SSRI）抗抑郁药，以及出生在非抑郁、非药物对照组的婴儿在出生后第一年的生长情况。方法：在这项前瞻性观察研究中，对妊娠20周、30周和36周的孕妇进行评估，并在产后2周、12周、26周和52周对母婴进行评估。根据妊娠暴露情况将女性分为三组：1)无SSRI且无抑郁（N=97）， 2) SSRI (N=46), 3)无SSRI的重度抑郁（N=31）。对不同暴露组的产妇人口学、临床特征和新生儿结局进行比较。在每个产后时间点，由医师或医师助理测量婴儿体重、身长和头围，他们对抑郁症和SSRI暴露状态一无所知。结果：调整后和未调整后的分析均显示，产前重度抑郁和SSRI暴露与婴儿体重、身长或头围均无显著相关性。此外，还评估了群体与孕前体重指数的相互作用，未发现显著的协同效应。同样，各组在体重、长度或头围方面也没有观察到不同时间的差异效应。结论：在子宫内暴露于重度抑郁症或SSRI抗抑郁药物对婴儿从出生到12个月的体重、身长或头围的生长没有影响。（美国精神病学杂志2013；170:485-493）
Objective: The aim of this study was to compare the growth of infants born to women with antenatal major depressive disorder, either untreated or treated with selective serotonin reuptake inhibitor (SSRI) antidepressants, and infants born to a nondepressed, nonmedicated comparison group across the first year of life.Method: In this prospective observational study, pregnant women were evaluated at weeks 20, 30, and 36 of gestation, and mother and infant pairs were assessed at 2, 12, 26, and 52 weeks postpartum. Three nonoverlapping groups of women were defined according to their pregnancy exposures: 1) no SSRI and no depression (N=97), 2) SSRI (N=46), and 3) major depression without SSRI (N=31). Maternal demographic and clinical characteristics and newborn outcomes were compared across exposure groups. Infant weight, length, and head circumference were measured by a physician or physician's assistant who was blind to depression and SSRI exposure status at each postpartum time point.Results: Both adjusted and unadjusted analyses revealed neither antenatal major depression nor SSRI exposure was significantly associated with infant weight, length, or head circumference relative to nonexposure to either. In addition, the interaction of group and prepregnancy body mass index was also evaluated, and no significant synergistic effect was identified. Similarly, no differential effect of group over time was observed for weight, length, or head circumference.Conclusions: In utero exposure to major depression or SSRI antidepressants did not affect infant growth with respect to weight, length, or head circumference from birth through 12 months of age. (Am J Psychiatry 2013; 170:485-493)