A spatiotemporal profile of visual system activation revealed by current source density analysis in the awake macaque.
A spatiotemporal profile of visual system activation revealed by current source density analysis in the awake macaque.
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DOI：
10.1093/cercor/8.7.575
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发表时间：
1998-10
期刊：
影响因子：
3.7
通讯作者：
C. Schroeder;A. Mehta;S. Givre
中科院分区：
文献类型：
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作者：
C. Schroeder;A. Mehta;S. Givre
我们研究了清醒猴子大脑皮层区域由一种视觉刺激产生的时空激活模式。突触后电位和动作电位的层状分布分别用电流源密度（CSD）和多单元活动分布进行索引。在局部，我们发现背侧流区域和腹侧流区域的激活曲线存在对比。前者与 V1 和 V2 一样，表现出“前馈”分布，激发从层 4 的深度开始，然后激活颗粒外层。后者通常表现出多层/柱状轮廓，初始响应分布在整个层中并反映调制而不是激励； CSD 成分要么没有变化，要么伴随着动作电位的抑制。在系统范围内，响应延迟表明背侧/腹侧流延迟优势较大，这可以推广到多种方法。这预测了视觉分析的背侧和腹侧流成分的特定时间顺序，以及背腹侧流相互作用的特定模式。我们的研究结果支持结合了串行和并行元素的皮质组织分层模型。这种模型的关键是要认识到，一个位置内的处理通常需要多个时间成分或活动“波”，由视网膜通过异构路径传递的输入驱动。
We investigated the spatiotemporal activation pattern, produced by one visual stimulus, across cerebral cortical regions in awake monkeys. Laminar profiles of postsynaptic potentials and action potentials were indexed with current source density (CSD) and multiunit activity profiles respectively. Locally, we found contrasting activation profiles in dorsal and ventral stream areas. The former, like V1 and V2, exhibit a 'feedforward' profile, with excitation beginning at the depth of Lamina 4, followed by activation of the extragranular laminae. The latter often displayed a multilaminar/columnar profile, with initial responses distributed across the laminae and reflecting modulation rather than excitation; CSD components were accompanied by either no changes or by suppression of action potentials. System-wide, response latencies indicated a large dorsal/ventral stream latency advantage, which generalizes across a wide range of methods. This predicts a specific temporal ordering of dorsal and ventral stream components of visual analysis, as well as specific patterns of dorsal-ventral stream interaction. Our findings support a hierarchical model of cortical organization that combines serial and parallel elements. Critical in such a model is the recognition that processing within a location typically entails multiple temporal components or 'waves' of activity, driven by input conveyed over heterogeneous pathways from the retina.