Association of polymorphisms in grainyhead-like-2 gene with the susceptibility to age-related hearing loss A systematic review and meta-analysis
Association of polymorphisms in grainyhead-like-2 gene with the susceptibility to age-related hearing loss A systematic review and meta-analysis
复制标题
Grainyhead-like-2基因多态性与年龄相关性听力损失易感性的关联系统评价和荟萃分析
DOI：
10.1097/md.0000000000016128
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发表时间：
2019
期刊：
影响因子：
1.6
通讯作者：
Sun Haiying
中科院分区：
文献类型：
--
作者：
Han Baoai;Yang Xiuping;Li Yongqin;Hosseini Davood K;Tu Yaqin;Dong Yaodong;He Zuhong;Yuan Jie;Cai Hua;Zhang Kai;Zhang Xiujuan;Zhou Tao;Sun Haiying
目的：在多项病例对照研究中，发现GRHL 2基因变异与年龄相关性听力损伤（ARHI）易感性有关。然而，他们的结论是相互矛盾的;很难精确评估与变异相关的疾病风险。方法：检索万方数据库、中国知网（CNKI）、EMBASE、Web of Science、PubMed（更新至2018年8月30日）等网络数据库中的相关文献。采用Review Manager 5.0和Stata SE 12.0软件，根据异质性检验中的I2值，计算随机效应模型和固定效应模型中的比值比（OR）、95%可信区间（CI）和P值。rs 10955255多态性的合并OR（95%CI）为1.26（1.05-1.50，P=. 01）、1.33（1.07-1.65，P=. 01）、1.32（1.12-1.55，P=. 0007）分别在等位基因、纯合子和隐性模型中。混合群体中rs 1981361分别与等位基因、杂合子和显性遗传模型中的ARHI风险显著相关。结果：rs 10955255基因多态性在高加索人群中与等位基因模式、纯合子模式、显性模式和隐性模式均存在显著关联，而在亚洲人群中与5种遗传模式均无关联。结论：rs 10955255基因多态性可能是ARHI的一个重要危险因素，尤其是在高加索人群中。rs 1981361多态性可能是亚洲人ARHI的危险因素。需要进行更大规模的研究，以进一步更新结果。
Objective:The grainyhead-like-2 (GRHL2) genetic variants were reported in age-related hearing impairment (ARHI) susceptibility in several case–control studies. However, their conclusions are conflicting; it is difficult to precisely assess the disease risk associated with the variants. Therefore we conduct the meta-analysis to discover the association of GRHL2 polymorphisms and the risk of ARHI.Methods:A related literature search was conducted in on-line databases, such as Wanfang database, China National Knowledge Infrastructure (CNKI), EMBASE, Web of Science, and PubMed (updated to August 30, 2018). We use Review Manager 5.0 and Stata SE 12.0 software to reckon the odds radio (OR), 95% confidence interval (CI) and P value in random-or fixed-effects model according to the I2 value in the heterogeneity test.Results:2762 cases and 2321 controls in 5 articles were provided data to the meta-analysis. The pooled ORs (95% CI) of the rs10955255 polymorphism were 1.26 (1.05–1.50, P=. 01), 1.33 (1.07–1.65, P=. 01), and 1.32 (1.12–1.55, P=. 0007) in the allele, homozygote and recessive model separately. Besides, a significant association was detected between rs1981361 in mixed population and the ARHI risk in the allele, heterozygote, and dominant genetic model respectively. Then subgroup analyses was performed by ethnicity, for rs10955255 meaningful associations were detected for the allele model, homozygote model, dominant model and recessive model in the Caucasian population but no relations in any of the 5 genetic models in Asian population.Conclusion:The meta-analysis indicated that the rs10955255 polymorphism could be an important risk factor for ARHI, especially in the Caucasians. The rs1981361 polymorphism may be a risk factor for ARHI in Asians. Larger scale researches are needed to further bring the consequences up to date.