White matter changes in dementia with Lewy bodies and Alzheimer's disease: A tractography-based study
White matter changes in dementia with Lewy bodies and Alzheimer's disease: A tractography-based study
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DOI：
10.1016/j.jpsychires.2011.01.011
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发表时间：
2011-08-01
影响因子：
4.8
通讯作者：
Kishimoto, Toshifumi
中科院分区：
文献类型：
--
作者：
Kiuchi, Kuniaki;Morikawa, Masayuki;Kishimoto, Toshifumi
路易体痴呆（DLB）和阿尔茨海默病（AD）是不同类型的痴呆。然而，他们的临床症状部分重叠和鉴别诊断有时是困难的。需要额外的诊断标准来可靠地区分这两种情况。同时，一些影像学研究显示DLB和AD之间的结果不一致。本研究的目的是使用纤维束成像为基础的分析，以阐明白色物质的变化与DLB与AD和对照组相比。了解AD、DLB和对照组之间的白色连接差异将有助于鉴别诊断和了解病理生理学。26例DLB受试者，26例AD受试者和26例对照者进行了磁共振扩散张量成像和神经心理学评估。使用“dTV II”软件计算扩散张量并创建纤维束图。我们测量了钩椎束（INCINE）、枕额下束（IOFF）和下纵束（ILF）沿着平均各向异性分数（FA）值。与对照组相比，DLB和AD受试者的双侧延髓FA值均较低。与对照组相比，DLB受试者的IOFF两侧和ILF左侧的FA值显著降低。尽管DLB和AD受试者之间的任何测量结果均无显著差异，但DLB受试者的FA值较低，尤其是在视觉相关的白色物质中。这些不同的变化，白色束组之间可能有助于鉴别诊断和理解的病理生理。(C)2011爱思唯尔有限公司保留所有权利。
Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are different types of dementia. However, their clinical symptoms partially overlap and differential diagnosis is occasionally difficult. There is need for additional diagnostic criteria to reliably differentiate between these two conditions. Meanwhile, several imaging studies have showed inconsistent results between DLB and AD. The aim of this study was to use a tractography-based analysis to elucidate white matter alterations in subjects with DLB compared to those with AD and to controls. An understanding of the white matter connectivity differences between AD, DLB and controls will be helpful for differential diagnosis and an understanding of the pathophysiology. Twenty-six subjects with DLB, 26 with AD and 26 controls underwent magnetic resonance diffusion tensor imaging and neuropsychological assessment. Diffusion tensors were computed and fiber-tract maps were created using "dTV II" software. We measured mean fractional anisotropy (FA) values along the uncinate fasciculus (UNC), the inferior occipitofrontal fasciculus (IOFF) and the inferior longitudinal fasciculus (ILF). Both subjects with DLB and AD had lower FA values for the bilateral UNC than controls. Subjects with DLB exhibited significantly lower FA values on both sides of the IOFF and the left side of the ILF than those of controls. Although there were no significant differences between subjects with DLB and AD for any measurements, those with DLB exhibited lower FA values especially in visual-related white matter. These different changes in white matter tracts among groups could be helpful for differential diagnosis and an understanding of the pathophysiology. (C) 2011 Elsevier Ltd. All rights reserved.