Developmental programming: Cumulative effects of increased pre-hatching corticosterone levels and post-hatching unpredictable food availability on physiology and behaviour in adulthood
Developmental programming: Cumulative effects of increased pre-hatching corticosterone levels and post-hatching unpredictable food availability on physiology and behaviour in adulthood
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DOI：
10.1016/j.yhbeh.2013.07.002
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发表时间：
2013-08-01
影响因子：
3.5
通讯作者：
Spencer, Karen A.
中科院分区：
文献类型：
--
作者：
Zimmer, Cedric;Boogert, Neeltje J.;Spencer, Karen A.
在发育过程中长期暴露在压力下可能会对健康和福祉产生长期有害影响。然而，环境匹配假说提出，发育压力以一种适应性的方式规划生理和行为，如果早期的环境与后来经历的环境相匹配，那么这种方式可以增强健康。大多数研究都集中在早期生活中的一段时期的压力对成年后可能产生的有害影响。在这项研究中，我们测试了在孵化前和孵化后的发育过程中，应激对成虫的生理和行为可能产生的潜在的附加和有益的影响。日本鹌鹑在两个发育阶段经历了不同的应激处理：孵化前皮质酮(CORT)注射、孵化后不可预测的食物可获得性、孵化前和孵化后的处理，或对照。成年后，我们测定了它们的急性应激反应、新恐惧症和对新环境的探索。孵化前的皮质醇处理导致对急性应激源的生理反应减弱，活动水平增加，并在新环境中进行探索。孵化后不可预测的食物供应减少了成虫进食的潜伏期。此外，这些处理在两个发育阶段都有累积效应：在所有处理组中，接受孵化前和孵化后处理的鹌鹑是最具探索性和风险的。这种对新环境的反应可以在以后的生活中提高在不可预测环境中的存活率。我们的数据还表明，这些行为反应可能是通过肾上腺皮质应激反应的长期生理编程来调节的，创造的表型可能在变化的环境中表现出增强健康的行为。(C)2013年提交人。爱思唯尔公司出版，版权所有。
Prolonged exposure to stress during development can have long-term detrimental effects on health and wellbeing. However, the environmental matching hypothesis proposes that developmental stress programs physiology and behaviour in an adaptive way that can enhance fitness if early environments match those experienced later in life. Most research has focused on the harmful effects that stress during a single period in early life may exert in adulthood. In this study, we tested the potential additive and beneficial effects that stress experienced during both pre- and post-hatching development may have on adult physiology and behaviour. Japanese quail experienced different stress-related treatments across two developmental life stages: pre-hatching corticosterone (CORT) injection, post-hatching unpredictable food availability, both pre- and post-hatching treatments, or control. In adulthood, we determined quails' acute stress response, neophobia and novel environment exploration. The pre-hatching CORT treatment resulted in attenuated physiological responses to an acute stressor, increased activity levels and exploration in a novel environment. Post-hatching unpredictable food availability decreased adults' latency to feed. Furthermore, there were cumulative effects of these treatments across the two developmental stages: quail subjected to both pre- and post-hatching treatments were the most explorative and risk-taking of all treatment groups. Such responses to novel environments could enhance survival in unpredictable environments in later life. Our data also suggest that these behavioural responses may have been mediated by long-term physiological programming of the adrenocortical stress response, creating phenotypes that could exhibit fitness-enhancing behaviours in a changing environment. (c) 2013 The Authors. Published by Elsevier Inc All rights reserved.