Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy
Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy
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DOI：
10.1016/j.yebeh.2003.10.010
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发表时间：
2004-02-01
影响因子：
2.6
通讯作者：
Cendes, F
中科院分区：
文献类型：
--
作者：
Alessio, A;Damasceno, BP;Cendes, F
内侧颞叶癫痫（MTLE）通常伴随海马系统损伤导致的记忆缺陷。然而，在大多数研究中，海马萎缩（HA）的影响与其他变量相混淆，例如：初始诱发损伤的类型和病理基础、病变（HA）偏侧化的影响、热性惊厥史、癫痫持续状态、癫痫发作年龄、癫痫持续时间、癫痫发作频率和抗癫痫药物（AED）。为了研究记忆缺陷与这些变量之间的关系，我们研究了 20 名 MTLE 患者且 MRI 上有 HA 体征，以及 15 名具有正常高分辨率 MRI 的 MTLE 患者。研究结果表明，（1）HA、癫痫发作较早、癫痫持续时间较长、癫痫发作频率较高以及AED（多药疗法）与记忆缺陷有关； (2)语言记忆缺陷与左脑透明质酸之间存在密切关系，但视觉记忆与右脑透明质酸之间没有密切关系。 (C) 2003 Elsevier Inc. 保留所有权利。
Mesial temporal lobe epilepsy (MTLE) is usually accompanied by memory deficits due to damage to the hippocampal system. In most studies, however, the influence of hippocampal atrophy (HA) is confounded with other variables, such as: type of initial precipitating injury and pathological substrate, effect of lesion (HA) lateralization, history of febrile seizures, status epilepticus, age of seizure onset, duration of epilepsy, seizure frequency, and antiepileptic drugs (AEDs). To investigate the relationship between memory deficits and these variables, we studied 20 patients with MTLE and signs of HA on MRI and 15 MTLE patients with normal high-resolution MRI. The findings indicated that (1) HA, earlier onset of seizures, longer duration of epilepsy, higher seizure frequency, and AEDs (polytherapy) are associated with memory deficits; and (2) there is a close relationship between deficits of verbal memory and left HA, but not between visual memory and right HA. (C) 2003 Elsevier Inc. All rights reserved.