Mouse model of Staphylococcus aureus skin infection.
Mouse model of Staphylococcus aureus skin infection.
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DOI：
10.1007/978-1-62703-481-4_14
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发表时间：
2013-01-01
期刊：
影响因子：
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通讯作者：
DeLeo, Frank R
中科院分区：
文献类型：
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作者：
Malachowa, Natalia;Kobayashi, Scott D;DeLeo, Frank R
细菌性皮肤和软组织感染在世界范围内大量存在，许多是由金黄色葡萄球菌引起的。事实上，S。金黄色葡萄球菌是美国皮肤和软组织感染的主要原因。在这里，我们描述了一种小鼠模型的皮肤和软组织感染诱导皮下接种的S。金黄色。该动物模型可用于研究与皮肤和软组织感染的发病机制相关的许多因素，包括菌株毒力和特定细菌分子对疾病的贡献，并且可用于测试抗生素疗法或候选疫苗的潜在有效性。
Bacterial skin and soft tissue infections are abundant worldwide and many are caused by Staphylococcus aureus. Indeed, S. aureus is the leading cause of skin and soft tissue infections in the USA. Here, we describe a mouse model of skin and soft tissue infection induced by subcutaneous inoculation of S. aureus. This animal model can be used to investigate a number of factors related to the pathogenesis of skin and soft tissue infections, including strain virulence and the contribution of specific bacterial molecules to disease, and it can be employed to test the potential effectiveness of antibiotic therapies or vaccine candidates.