Comparing rib cortical thickness measurements from computed tomography (CT) and Micro-CT.
Comparing rib cortical thickness measurements from computed tomography (CT) and Micro-CT.
复制标题
比较计算机断层扫描 (CT) 和 Micro-CT 的肋骨皮质厚度测量结果。
DOI：
10.1016/j.compbiomed.2019.103330
复制
发表时间：
2019
影响因子：
7.7
通讯作者：
Weaver,AshleyA
中科院分区：
文献类型：
--
作者：
Hostetler,ZacharyS;Stitzel,JoelD;Weaver,AshleyA
本研究的目的是比较临床计算机断层扫描（临床ct）在0.5和1.0 mm层厚和显微ct在0.05 mm层厚扫描肋骨标本的皮质厚度。通过解剖区域（前部与外侧）和横断面象限（上、内、下、外）来探讨皮质厚度的变化和准确性。方法应用sa验证的皮质厚度算法对6例42 ~ 81岁男性死后人体17例肋骨标本进行临床ct和显微ct扫描。每个肋骨标本被分割，厚度测量被划分为肋骨前部和外侧区域的横截面象限。在每个肋骨象限内计算：平均厚度 ± 标准差，临床ct与微型ct的平均厚度差，临床ct与微型ct的厚度比。通过线性回归和配对t检验确定配对临床ct和显微ct结果的相关性。结果0.5 mm的临床ct平均低估微ct厚度0.005 mm， 1.0 mm的临床ct平均高估微ct厚度0.149 mm。与1.0 mm临床ct相比，0.5 mm临床ct的厚度与micro-CT的厚度表现出更显著的线性相关性（p < 0.05）。结论皮质厚度算法应用于肋骨临床ct扫描时，平均差值较小，厚度比接近1，表明该算法是有效的。使用临床CT扫描作为一种精确测量肋骨皮质厚度的方法，为分析每年从所有年龄段的男性和女性收集的数百万CT扫描提供了一种非侵入性的方法。
BackgroundThe objective of this study was to compare cortical thickness of rib specimens scanned with clinical computed tomography (clinical-CT) at 0.5 and 1.0 mm slice thickness versus micro-CT at 0.05 mm slice thickness. Cortical thickness variation and accuracy was explored by anatomical region (anterior vs. lateral) and cross-sectional quadrants (superior, interior, inferior, and exterior).MethodsA validated cortical thickness algorithm was applied to clinical-CT and micro-CT scans of 17 rib specimens from six male post mortem human subjects aged 42–81 years. Each rib specimen was segmented and the thickness measurements were partitioned into cross-sectional quadrants in the anterior and lateral regions of the rib. Within each rib quadrant, the following were calculated: average thickness ± standard deviation, mean thickness difference between clinical-CT and micro-CT, and a thickness ratio between clinical-CT and micro-CT. Correlations from linear regression and paired-t tests were determined for paired clinical-CT and micro-CT results.ResultsOn average, the 0.5 mm clinical-CT underestimated the micro-CT thickness by 0.005 mm, while the 1.0 mm clinical-CT overestimated the micro-CT thickness by 0.149 mm. Thickness derived from 0.5 mm clinical-CT showed greater significant linear correlations (p < 0.05) with micro-CT thickness compared to 1.0 mm clinical-CT.ConclusionsThe small mean differences and thickness ratios near 1 show validation for the cortical thickness algorithm when applied to rib clinical-CT scans. Using clinical-CT scans as way to accurately measure rib cortical thickness offers a non-invasive way to analyze millions of CT scans collected each year from males and females of all ages.