A-G PROTEIN COUPLES SEROTONIN AND GABA-B RECEPTORS TO THE SAME CHANNELS IN HIPPOCAMPUS
A-G PROTEIN COUPLES SEROTONIN AND GABA-B RECEPTORS TO THE SAME CHANNELS IN HIPPOCAMPUS
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DOI：
10.1126/science.2430334
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发表时间：
1986-12-05
期刊：
影响因子：
56.9
通讯作者：
NICOLL, RA
中科院分区：
文献类型：
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作者：
ANDRADE, R;MALENKA, RC;NICOLL, RA
血清素和选择性 γ-氨基丁酸 B (GABAB) 激动剂巴氯芬均增加海马锥体细胞中的钾 (K+) 电导。尽管这些激动剂作用于不同的受体，但激动剂引起的钾电流不是相加的，这表明这两种受体共享相同的钾通道。使用抗水解鸟苷三磷酸 (GTP) 和鸟苷二磷酸类似物以及百日咳毒素的实验表明，血清素和 GABAB 受体打开钾通道涉及百日咳毒素敏感的 GTP 结合 (G) 蛋白，该蛋白可能直接将两种受体与钾通道偶联。
Both serotonin and the selective .gamma.-aminobutyric acidB (GABAB) agonist, baclofen, increase potassium (K+) conductance in hippocampal pyramidal cells. Although these agonists act on separate receptors, the potassium currents evoked by the agonists are not additive, indicating that the two receptors share the same potassium channels. Experiments with hydrolysis-resistant guanosine triphosphate (GTP) and guanosine diphosphate analogs and pertussis toxin indicate that the opening of the potassium channels by serotonin and GABAB receptors involves a pertussis toxin-sensitive GTP-binding (G) protein, which may directly couple the two receptors to the potassium channel.