Do steroids interfere in dyspnoea sensation?
Do steroids interfere in dyspnoea sensation?
复制标题
类固醇会干扰呼吸困难的感觉吗？
作者：
F. Kallas de Carvalho;J. Filho;E. Vianna;G. Silva;J. B. Martinez
呼吸困难仍然是一个显著的临床问题和治疗挑战，主要是在慢性呼吸疾病。本研究调查了类固醇对呼吸困难感觉的潜在影响，无论其肺部抗炎作用如何。16名健康男性（平均年龄+/- SD = 22.5 +/- 1.6岁）在服用40 mg泼尼松（Pred）或安慰剂（Plac）后6 h，通过使用吸气阻力器（负荷为0、7、14和21 cm H2O/l/s）和屏气出现呼吸不适。使用100 mm视觉模拟量表评价负荷呼吸期间的呼吸不适。最长自主呼吸暂停时间在强的松组和安慰剂组之间没有差异（Plac = 96 +/- 11.8 s x Pred = 105 +/- 12.2 s）和泼尼松对不同吸气负荷引起的呼吸困难感觉无影响（0 cm H2O/l/s：Pred = 2.8 mm x Plac = 1.9 mm; 7 cm H2O/l/s：Pred = 18.3 mm x Plac = 18.6 mm; 14 cm H2O/l/s; Pred = 33.0 mm x Plac = 34.1 mm; 21 cm H2O/l/s：Pred = 48.1 mm x Plac = 49.6 mm）。泼尼松摄入与无吸气负荷呼吸期间分钟通气量显著增加相关（Pred = 11.91 +/- 1.28 l/min- x Plac = 9.95 +/- 0.86 l/min）。虽然类固醇由于抗炎作用肯定可以改善呼吸状况，但现有证据不支持这些药物对呼吸困难本身的这些感知有任何特定的有益作用。
Dyspnoea remains a remarkable clinical problem and a therapeutic challenge, mainly in chronic respiratory conditions. This study investigated the potential effects of steroids on dyspnoea sensation regardless of their pulmonary anti-inflammatory actions. Sixteen healthy men (mean age +/- SD = 22.5 +/- 1.6 years) developed uncomfortable breathing by the use of inspiratory resistors (loads of 0, 7, 14 and 21 cm H2O/l/s) and breathholding 6 h after taking 40 mg of prednisone (Pred) or placebo (Plac). Respiratory discomfort during breathing with loads was evaluated with a 100 mm visual analog scale. The maximum voluntary apnoea time did not differ between the prednisone and placebo days (Plac = 96 +/- 11.8 s x Pred = 105 +/- 12.2 s) and prednisone did not influence the dyspnoea sensation induced by different inspiratory loads (0 cm H2O/l/s: Pred = 2.8 mm x Plac = 1.9 mm; 7 cm H2O/l/s: Pred = 18.3 mm x Plac = 18.6 mm; 14 cm H2O/l/s; Pred = 33.0 mm x Plac = 34.1 mm; 21 cm H2O/l/s: Pred = 48.1 mm x Plac = 49.6 mm). Prednisone intake was associated with a significant increase in minute ventilation during breathing with no inspiratory loads (Pred = 11.91 +/- 1.28 l/min- x Plac = 9.95 +/- 0.86 l/min). Although steroids certainly may improve respiratory conditions due to anti-inflammatory actions, available evidence does not support any specific beneficial effect of these drugs on these perception of dyspnoea itself.
神经类固醇：生物化学、作用方式和临床相关性。
DOI：
10.1210/jcem.78.5.8175951
发表时间：
1994
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Mellon,SH
通讯作者：
Mellon,SH