The effects of feeding a zinc-deficient diet on taste acuity and tongue epithelium in rats.
The effects of feeding a zinc-deficient diet on taste acuity and tongue epithelium in rats.
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喂养缺锌饮食对大鼠味觉敏锐度和舌上皮的影响。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
R. Nanda
中科院分区：
文献类型：
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作者：
F. Catalanotto;R. Nanda
味觉偏好，液体摄入量和组织学的舌上皮细胞进行了研究，在大鼠喂养的缺锌饮食和配对喂养的控制。两瓶偏爱性实验结果表明，缺锌大鼠对1.5 × 10 ~（-1）M盐酸和1.28 × 10 ~（-6）M硫酸奎宁的偏爱性显著增加，相对液体摄入量也显著增加。锌缺乏大鼠舌上皮的组织学检查显示细胞增生的棘细胞层和明显的角化不全。缺锌大鼠的菌状乳头棘层增厚，轻度角化不全。然而，味蕾的孔区域似乎没有被角化不全上皮覆盖。结果表明，在缺锌大鼠中观察到的味觉受损可能与促味剂从毛孔区域的阻塞无关。
Taste preferences, fluid intake and histology of tongue epithelium were studied in rats fed a zinc-deficient diet and in pair-fed controls. The results of two-bottle preference tests demonstrated that zinc-deficient rats exhibited significantly increased preferences for 1.5 X 10(-1) M HCL and 1.28 X 10(-6) M quinine sulfate as well as a significant increase in relative fluid volume intake. Histologic examination of the tongue epithelium of the zinc-deficient rats showed a hypercellular prickle cell layer and a marked parakeratosis. The fungiform papillae of the zinc-deficient rats exhibited acanthosis and mild parakeratosis. However, the pore region of the taste buds did not seem to be covered by the parakeratotic epithelium. The results suggest that the impaired taste observed in zinc-deficient rats may not be related to blockage of tastants from the pore region.